The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing

The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing

The relationship between DNA damage response (DDR) and regulation of the tolerance to glucose restriction is currently unclear. Here the authors reveal that maintaining a physiological level of histones by Rad53-Spt21 is necessary for glucose tolerance via multiple parallel pathways, including derep...

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Autores principales: Christopher Bruhn, Arta Ajazi, Elisa Ferrari, Michael Charles Lanz, Renaud Batrin, Ramveer Choudhary, Adhish Walvekar, Sunil Laxman, Maria Pia Longhese, Emmanuelle Fabre, Marcus Bustamente Smolka, Marco Foiani
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/c1334c64c88341dd9b8f7f4e9f177694
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spelling oai:doaj.org-article:c1334c64c88341dd9b8f7f4e9f1776942021-12-02T18:00:10ZThe Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing10.1038/s41467-020-17961-42041-1723https://doaj.org/article/c1334c64c88341dd9b8f7f4e9f1776942020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17961-4https://doaj.org/toc/2041-1723The relationship between DNA damage response (DDR) and regulation of the tolerance to glucose restriction is currently unclear. Here the authors reveal that maintaining a physiological level of histones by Rad53-Spt21 is necessary for glucose tolerance via multiple parallel pathways, including derepression of subtelomeric genes and acetyl-coA regulation by histone acetylation.Christopher BruhnArta AjaziElisa FerrariMichael Charles LanzRenaud BatrinRamveer ChoudharyAdhish WalvekarSunil LaxmanMaria Pia LongheseEmmanuelle FabreMarcus Bustamente SmolkaMarco FoianiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Christopher Bruhn
Arta Ajazi
Elisa Ferrari
Michael Charles Lanz
Renaud Batrin
Ramveer Choudhary
Adhish Walvekar
Sunil Laxman
Maria Pia Longhese
Emmanuelle Fabre
Marcus Bustamente Smolka
Marco Foiani
The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing
description The relationship between DNA damage response (DDR) and regulation of the tolerance to glucose restriction is currently unclear. Here the authors reveal that maintaining a physiological level of histones by Rad53-Spt21 is necessary for glucose tolerance via multiple parallel pathways, including derepression of subtelomeric genes and acetyl-coA regulation by histone acetylation.
format article
author Christopher Bruhn
Arta Ajazi
Elisa Ferrari
Michael Charles Lanz
Renaud Batrin
Ramveer Choudhary
Adhish Walvekar
Sunil Laxman
Maria Pia Longhese
Emmanuelle Fabre
Marcus Bustamente Smolka
Marco Foiani
author_facet Christopher Bruhn
Arta Ajazi
Elisa Ferrari
Michael Charles Lanz
Renaud Batrin
Ramveer Choudhary
Adhish Walvekar
Sunil Laxman
Maria Pia Longhese
Emmanuelle Fabre
Marcus Bustamente Smolka
Marco Foiani
author_sort Christopher Bruhn
title The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing
title_short The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing
title_full The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing
title_fullStr The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing
title_full_unstemmed The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing
title_sort rad53chk1/chk2-spt21npat and tel1atm axes couple glucose tolerance to histone dosage and subtelomeric silencing
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/c1334c64c88341dd9b8f7f4e9f177694
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