Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Fakhar ud Din,1,* Waqar Aman,2,* Izhar Ullah,3 Omer Salman Qureshi,4 Omer Mustapha,5 Shumaila Shafique,6 Alam Zeb7 1Department of Pharmacy, Quaid-i-Azam University, Islamabad, 2Department of Pharmacy, Kohat University of Science and Technology, Kohat, 3Department of Health and Medical Sciences, Uni...

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Autores principales:	Din FU, Aman W, Ullah I, Qureshi OS, Mustapha O, Shafique S, Zeb A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Nano-carriers Drug delivery Solid lipid nanoparticles Liposomes Polymeric nanoparticles Dendrimers Breast tumor Lungs tumor Colorectal tumor Prostate tumor Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c1334c6f5d7e48ff8f799c5002986d03
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spelling	oai:doaj.org-article:c1334c6f5d7e48ff8f799c5002986d032021-12-02T01:01:50ZEffective use of nanocarriers as drug delivery systems for the treatment of selected tumors1178-2013https://doaj.org/article/c1334c6f5d7e48ff8f799c5002986d032017-10-01T00:00:00Zhttps://www.dovepress.com/effective-use-of-nanocarriers-as-drug-delivery-systems-for-the-treatme-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Fakhar ud Din,1,* Waqar Aman,2,* Izhar Ullah,3 Omer Salman Qureshi,4 Omer Mustapha,5 Shumaila Shafique,6 Alam Zeb7 1Department of Pharmacy, Quaid-i-Azam University, Islamabad, 2Department of Pharmacy, Kohat University of Science and Technology, Kohat, 3Department of Health and Medical Sciences, University of Poonch, Rawalakot, Azad Kashmir, 4Faculty of Pharmacy, University of Lahore, Lahore, 5Faculty of Pharmacy, Ziauddin University, Karachi, 6Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, 7Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan *These authors contributed equally to this work Abstract: Nanotechnology has recently gained increased attention for its capability to effectively diagnose and treat various tumors. Nanocarriers have been used to circumvent the problems associated with conventional antitumor drug delivery systems, including their nonspecificity, severe side effects, burst release and damaging the normal cells. Nanocarriers improve the bioavailability and therapeutic efficiency of antitumor drugs, while providing preferential accumulation at the target site. A number of nanocarriers have been developed; however, only a few of them are clinically approved for the delivery of antitumor drugs for their intended actions at the targeted sites. The present review is divided into three main parts: first part presents introduction of various nanocarriers and their relevance in the delivery of anticancer drugs, second part encompasses targeting mechanisms and surface functionalization on nanocarriers and third part covers the description of selected tumors, including breast, lungs, colorectal and pancreatic tumors, and applications of relative nanocarriers in these tumors. This review increases the understanding of tumor treatment with the promising use of nanotechnology. Keywords: nanocarriers, drug delivery, solid lipid nanoparticles, liposomes, polymeric nanoparticles, dendrimers, breast tumor, lungs tumor, colorectal tumor, prostate tumor Din FUAman WUllah IQureshi OSMustapha OShafique SZeb ADove Medical PressarticleNano-carriersDrug deliverySolid lipid nanoparticlesLiposomesPolymeric nanoparticlesDendrimersBreast tumorLungs tumorColorectal tumorProstate tumorMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 7291-7309 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nano-carriers Drug delivery Solid lipid nanoparticles Liposomes Polymeric nanoparticles Dendrimers Breast tumor Lungs tumor Colorectal tumor Prostate tumor Medicine (General) R5-920
spellingShingle	Nano-carriers Drug delivery Solid lipid nanoparticles Liposomes Polymeric nanoparticles Dendrimers Breast tumor Lungs tumor Colorectal tumor Prostate tumor Medicine (General) R5-920 Din FU Aman W Ullah I Qureshi OS Mustapha O Shafique S Zeb A Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
description	Fakhar ud Din,1,* Waqar Aman,2,* Izhar Ullah,3 Omer Salman Qureshi,4 Omer Mustapha,5 Shumaila Shafique,6 Alam Zeb7 1Department of Pharmacy, Quaid-i-Azam University, Islamabad, 2Department of Pharmacy, Kohat University of Science and Technology, Kohat, 3Department of Health and Medical Sciences, University of Poonch, Rawalakot, Azad Kashmir, 4Faculty of Pharmacy, University of Lahore, Lahore, 5Faculty of Pharmacy, Ziauddin University, Karachi, 6Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, 7Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan *These authors contributed equally to this work Abstract: Nanotechnology has recently gained increased attention for its capability to effectively diagnose and treat various tumors. Nanocarriers have been used to circumvent the problems associated with conventional antitumor drug delivery systems, including their nonspecificity, severe side effects, burst release and damaging the normal cells. Nanocarriers improve the bioavailability and therapeutic efficiency of antitumor drugs, while providing preferential accumulation at the target site. A number of nanocarriers have been developed; however, only a few of them are clinically approved for the delivery of antitumor drugs for their intended actions at the targeted sites. The present review is divided into three main parts: first part presents introduction of various nanocarriers and their relevance in the delivery of anticancer drugs, second part encompasses targeting mechanisms and surface functionalization on nanocarriers and third part covers the description of selected tumors, including breast, lungs, colorectal and pancreatic tumors, and applications of relative nanocarriers in these tumors. This review increases the understanding of tumor treatment with the promising use of nanotechnology. Keywords: nanocarriers, drug delivery, solid lipid nanoparticles, liposomes, polymeric nanoparticles, dendrimers, breast tumor, lungs tumor, colorectal tumor, prostate tumor
format	article
author	Din FU Aman W Ullah I Qureshi OS Mustapha O Shafique S Zeb A
author_facet	Din FU Aman W Ullah I Qureshi OS Mustapha O Shafique S Zeb A
author_sort	Din FU
title	Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
title_short	Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
title_full	Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
title_fullStr	Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
title_full_unstemmed	Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
title_sort	effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/c1334c6f5d7e48ff8f799c5002986d03
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Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

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