Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers

Aim. To analyse association of class II HLA genotype (DRB1, DQA1, DQB1) with type 1 diabetes mellitus (DM1) in an Udmurtian population. Materials and methods. The case-control method was applied in the study involving 29 children with DM1 and 97 age-matched healthy subjects. HLAalleles were identi...

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Autores principales:	Olga Nikolavna Ivanova, Sergey Alexandrovich Prokof'ev, Yana Stanislavovna Zvereva, Tatiana Viktorovna Kovalenko, Andrey Vladimirovich Blinov, Valentina Alexandrovna Peterkova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	dqa1 type 1 diabetes mellitus class ii hla drb1 dqb1 genes role of dq heterodimers udmurtian population Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/c1354ef0d7644f4ea194a46c7a1b43bb
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spelling	oai:doaj.org-article:c1354ef0d7644f4ea194a46c7a1b43bb2021-11-14T09:00:14ZClass II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers2072-03512072-037810.14341/2072-0351-5449https://doaj.org/article/c1354ef0d7644f4ea194a46c7a1b43bb2009-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5449https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To analyse association of class II HLA genotype (DRB1, DQA1, DQB1) with type 1 diabetes mellitus (DM1) in an Udmurtian population. Materials and methods. The case-control method was applied in the study involving 29 children with DM1 and 97 age-matched healthy subjects. HLAalleles were identified by multiprimer allele-specific PCR. Association with DM1 was evaluated from the OR-odds ratio. Calculations were made usingStatSoft and STATISTICA 6 programs. Results. The occurrence of ?classical? highly predisposing haplotypes in the studied Udmurtian population proved significantly lower than in otherCaucasoid populations (DRB104-DQA10301-DQB10302 - 2,6 vs 8-16% and DRB117(03)-DQA0501-DQB10201 - 3,6 vs 6-12,9%)trans-Encoded DQ heterodimers (DQA10301-DQB10201 and DQA10301-DQB10302) were shown to play the key role in determining the riskof DM1. They were found in 62,1% of the patients compared with 10,3% of control subjects (OR=14,2; pc=6Ч10-5). Conclusion. Positive DQA10301-DQB10302 or/and *0201 genotype is the most sensitive predictor of DM1 in the studied Udmurtian population.Olga Nikolavna IvanovaSergey Alexandrovich Prokof'evYana Stanislavovna ZverevaTatiana Viktorovna KovalenkoAndrey Vladimirovich BlinovValentina Alexandrovna PeterkovaEndocrinology Research Centrearticledqa1type 1 diabetes mellitusclass ii hla drb1dqa1dqb1 genesrole of dq heterodimersudmurtian populationNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 3, Pp 33-36 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	dqa1 type 1 diabetes mellitus class ii hla drb1 dqa1 dqb1 genes role of dq heterodimers udmurtian population Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	dqa1 type 1 diabetes mellitus class ii hla drb1 dqa1 dqb1 genes role of dq heterodimers udmurtian population Nutritional diseases. Deficiency diseases RC620-627 Olga Nikolavna Ivanova Sergey Alexandrovich Prokof'ev Yana Stanislavovna Zvereva Tatiana Viktorovna Kovalenko Andrey Vladimirovich Blinov Valentina Alexandrovna Peterkova Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers
description	Aim. To analyse association of class II HLA genotype (DRB1, DQA1, DQB1) with type 1 diabetes mellitus (DM1) in an Udmurtian population. Materials and methods. The case-control method was applied in the study involving 29 children with DM1 and 97 age-matched healthy subjects. HLAalleles were identified by multiprimer allele-specific PCR. Association with DM1 was evaluated from the OR-odds ratio. Calculations were made usingStatSoft and STATISTICA 6 programs. Results. The occurrence of ?classical? highly predisposing haplotypes in the studied Udmurtian population proved significantly lower than in otherCaucasoid populations (DRB104-DQA10301-DQB10302 - 2,6 vs 8-16% and DRB117(03)-DQA0501-DQB10201 - 3,6 vs 6-12,9%)trans-Encoded DQ heterodimers (DQA10301-DQB10201 and DQA10301-DQB10302) were shown to play the key role in determining the riskof DM1. They were found in 62,1% of the patients compared with 10,3% of control subjects (OR=14,2; pc=6Ч10-5). Conclusion. Positive DQA10301-DQB10302 or/and *0201 genotype is the most sensitive predictor of DM1 in the studied Udmurtian population.
format	article
author	Olga Nikolavna Ivanova Sergey Alexandrovich Prokof'ev Yana Stanislavovna Zvereva Tatiana Viktorovna Kovalenko Andrey Vladimirovich Blinov Valentina Alexandrovna Peterkova
author_facet	Olga Nikolavna Ivanova Sergey Alexandrovich Prokof'ev Yana Stanislavovna Zvereva Tatiana Viktorovna Kovalenko Andrey Vladimirovich Blinov Valentina Alexandrovna Peterkova
author_sort	Olga Nikolavna Ivanova
title	Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers
title_short	Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers
title_full	Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers
title_fullStr	Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers
title_full_unstemmed	Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers
title_sort	class ii hla diabetogenic markers in an udmurtian population: genotype dependence, the role of dq trans-heterodimers
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/c1354ef0d7644f4ea194a46c7a1b43bb
work_keys_str_mv	AT olganikolavnaivanova classiihladiabetogenicmarkersinanudmurtianpopulationgenotypedependencetheroleofdqtransheterodimers AT sergeyalexandrovichprokofev classiihladiabetogenicmarkersinanudmurtianpopulationgenotypedependencetheroleofdqtransheterodimers AT yanastanislavovnazvereva classiihladiabetogenicmarkersinanudmurtianpopulationgenotypedependencetheroleofdqtransheterodimers AT tatianaviktorovnakovalenko classiihladiabetogenicmarkersinanudmurtianpopulationgenotypedependencetheroleofdqtransheterodimers AT andreyvladimirovichblinov classiihladiabetogenicmarkersinanudmurtianpopulationgenotypedependencetheroleofdqtransheterodimers AT valentinaalexandrovnapeterkova classiihladiabetogenicmarkersinanudmurtianpopulationgenotypedependencetheroleofdqtransheterodimers
_version_	1718429677552402432

Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers

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