Telomere length variation in juvenile acute myocardial infarction.

Leukocyte telomere length (LTL) provides a potential marker of biological age, closely related to the endothelial dysfunction and consequently to the atherosclerotic process. To investigate the relationship between the LTL and the risk of premature acute myocardial infarction and to evaluate the pre...

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Autores principales:	Alessia Russo, Luigi Palumbo, Cristina Fornengo, Cornelia Di Gaetano, Fulvio Ricceri, Simonetta Guarrera, Rossana Critelli, Matteo Anselmino, Alberto Piazza, Fiorenzo Gaita, Serena Bergerone, Giuseppe Matullo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c1372565114f485e9a64ba24a374b8fa
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spelling	oai:doaj.org-article:c1372565114f485e9a64ba24a374b8fa2021-11-18T08:09:31ZTelomere length variation in juvenile acute myocardial infarction.1932-620310.1371/journal.pone.0049206https://doaj.org/article/c1372565114f485e9a64ba24a374b8fa2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23145125/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Leukocyte telomere length (LTL) provides a potential marker of biological age, closely related to the endothelial dysfunction and consequently to the atherosclerotic process. To investigate the relationship between the LTL and the risk of premature acute myocardial infarction and to evaluate the predictive value of LTL on the onset of major cardiovascular events, 199 patients from 18 to 48 years old with first diagnosis of acute myocardial infarction were enrolled and were matched with 190 controls for sex and age (± 1 year). Clinical data and coronary artery disease were evaluated at enrollment and at follow up. LTL was measured at enrollment using a quantitative PCR-based method. No significant differences were observed in LTL between cases and controls (p = 0.20) and with the presence of coronary artery disease in patients (p = 0.47). Hypercholesterolemic cases presented LTL significantly longer than cases without hypercholesterolemia (t/s: 0.82 ± 0.16 p = 0.79 and t/s norm: 0.79 ± 0.19 p = 0.01), as confirmed in multivariate regression analysis (p = 0.005, β = 0.09). Furthermore, multivariate regression analysis showed LTL significantly shorter in hypertensive cases than in normotensive cases (p = 0.04, β = -0.07). One hundred seventy-one cases (86%) ended the average follow up of 9 ± 5 years, 92 (54%) presented a major cardiovascular event. At multivariate regression analysis the LTL detected at enrollment did not represent a predictive factor of major cardiovascular events nor it significantly impacted with cumulative events. Based on present cohort of young Italian patients, the LTL did not represent a marker of acute myocardial infarction nor had a predictive role at medium term follow up.Alessia RussoLuigi PalumboCristina FornengoCornelia Di GaetanoFulvio RicceriSimonetta GuarreraRossana CritelliMatteo AnselminoAlberto PiazzaFiorenzo GaitaSerena BergeroneGiuseppe MatulloPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49206 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alessia Russo Luigi Palumbo Cristina Fornengo Cornelia Di Gaetano Fulvio Ricceri Simonetta Guarrera Rossana Critelli Matteo Anselmino Alberto Piazza Fiorenzo Gaita Serena Bergerone Giuseppe Matullo Telomere length variation in juvenile acute myocardial infarction.
description	Leukocyte telomere length (LTL) provides a potential marker of biological age, closely related to the endothelial dysfunction and consequently to the atherosclerotic process. To investigate the relationship between the LTL and the risk of premature acute myocardial infarction and to evaluate the predictive value of LTL on the onset of major cardiovascular events, 199 patients from 18 to 48 years old with first diagnosis of acute myocardial infarction were enrolled and were matched with 190 controls for sex and age (± 1 year). Clinical data and coronary artery disease were evaluated at enrollment and at follow up. LTL was measured at enrollment using a quantitative PCR-based method. No significant differences were observed in LTL between cases and controls (p = 0.20) and with the presence of coronary artery disease in patients (p = 0.47). Hypercholesterolemic cases presented LTL significantly longer than cases without hypercholesterolemia (t/s: 0.82 ± 0.16 p = 0.79 and t/s norm: 0.79 ± 0.19 p = 0.01), as confirmed in multivariate regression analysis (p = 0.005, β = 0.09). Furthermore, multivariate regression analysis showed LTL significantly shorter in hypertensive cases than in normotensive cases (p = 0.04, β = -0.07). One hundred seventy-one cases (86%) ended the average follow up of 9 ± 5 years, 92 (54%) presented a major cardiovascular event. At multivariate regression analysis the LTL detected at enrollment did not represent a predictive factor of major cardiovascular events nor it significantly impacted with cumulative events. Based on present cohort of young Italian patients, the LTL did not represent a marker of acute myocardial infarction nor had a predictive role at medium term follow up.
format	article
author	Alessia Russo Luigi Palumbo Cristina Fornengo Cornelia Di Gaetano Fulvio Ricceri Simonetta Guarrera Rossana Critelli Matteo Anselmino Alberto Piazza Fiorenzo Gaita Serena Bergerone Giuseppe Matullo
author_facet	Alessia Russo Luigi Palumbo Cristina Fornengo Cornelia Di Gaetano Fulvio Ricceri Simonetta Guarrera Rossana Critelli Matteo Anselmino Alberto Piazza Fiorenzo Gaita Serena Bergerone Giuseppe Matullo
author_sort	Alessia Russo
title	Telomere length variation in juvenile acute myocardial infarction.
title_short	Telomere length variation in juvenile acute myocardial infarction.
title_full	Telomere length variation in juvenile acute myocardial infarction.
title_fullStr	Telomere length variation in juvenile acute myocardial infarction.
title_full_unstemmed	Telomere length variation in juvenile acute myocardial infarction.
title_sort	telomere length variation in juvenile acute myocardial infarction.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c1372565114f485e9a64ba24a374b8fa
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Telomere length variation in juvenile acute myocardial infarction.

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