Regulatory Effect of Resveratrol on Inflammation Induced by Lipopolysaccharides via Reprograming Intestinal Microbes and Ameliorating Serum Metabolism Profiles

The purpose of this study was to explore the regulatory effect of resveratrol (RES) on lipopolysaccharide (LPS)-induced inflammation and its influence on intestinal microorganisms and serum atlas in murine models during the development of inflammation to explore a novel method for the regulation of...

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Autores principales:	Sujuan Ding, Hongmei Jiang, Jun Fang, Gang Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	resveratrol inflammation serum metabolites intestinal microbes DSS Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c137a28cb9014411b1d9b3a741ef485f
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spelling	oai:doaj.org-article:c137a28cb9014411b1d9b3a741ef485f2021-11-15T05:30:05ZRegulatory Effect of Resveratrol on Inflammation Induced by Lipopolysaccharides via Reprograming Intestinal Microbes and Ameliorating Serum Metabolism Profiles1664-322410.3389/fimmu.2021.777159https://doaj.org/article/c137a28cb9014411b1d9b3a741ef485f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.777159/fullhttps://doaj.org/toc/1664-3224The purpose of this study was to explore the regulatory effect of resveratrol (RES) on lipopolysaccharide (LPS)-induced inflammation and its influence on intestinal microorganisms and serum atlas in murine models during the development of inflammation to explore a novel method for the regulation of inflammation. Mice were randomly assigned to three groups: control (CON), LPS, and RES–LPS. The results showed that RES mitigated the inflammatory damage to the intes-tines and liver induced by LPS. Compared with the LPS group, RES treatment decreased the levels of TNF-α, IL-6, IFN-γ, myeloperoxidase, and alanine aminotransferase in the liver. Serum metabolic profile monitoring showed that, compared with the CON group, LPS decreased the levels of five metabolites, including cycloartomunin and glycerol triundecanoate, and increased the levels of eight metabolites, including N-linoleoyl taurine and PE(O-16:0/20:5(5Z), 8Z, 11Z, 14Z, 17Z). Conversely, RES treatment increased the levels of eight metabolites, including pantothenic acid, homovanillic acid, and S-(formylmethyl)glutathione, and reduced seven metabolites, including lysoPE(20:4(8Z,11Z,14Z,17Z)/0:0) and 13-cis-retinoic acid, etc., in comparison with the LPS group. Moreover, RES treatment alleviated the negative effects of LPS on intestinal microbes by reducing, for instance, the relative abundance of Bacteroidetes and Alistipes, and increasing the relative abundance of Lactobacillus. These results suggest that RES has great potential for preventing in-flammation.Sujuan DingHongmei JiangJun FangGang LiuFrontiers Media S.A.articleresveratrolinflammationserum metabolitesintestinal microbesDSSImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	resveratrol inflammation serum metabolites intestinal microbes DSS Immunologic diseases. Allergy RC581-607
spellingShingle	resveratrol inflammation serum metabolites intestinal microbes DSS Immunologic diseases. Allergy RC581-607 Sujuan Ding Hongmei Jiang Jun Fang Gang Liu Regulatory Effect of Resveratrol on Inflammation Induced by Lipopolysaccharides via Reprograming Intestinal Microbes and Ameliorating Serum Metabolism Profiles
description	The purpose of this study was to explore the regulatory effect of resveratrol (RES) on lipopolysaccharide (LPS)-induced inflammation and its influence on intestinal microorganisms and serum atlas in murine models during the development of inflammation to explore a novel method for the regulation of inflammation. Mice were randomly assigned to three groups: control (CON), LPS, and RES–LPS. The results showed that RES mitigated the inflammatory damage to the intes-tines and liver induced by LPS. Compared with the LPS group, RES treatment decreased the levels of TNF-α, IL-6, IFN-γ, myeloperoxidase, and alanine aminotransferase in the liver. Serum metabolic profile monitoring showed that, compared with the CON group, LPS decreased the levels of five metabolites, including cycloartomunin and glycerol triundecanoate, and increased the levels of eight metabolites, including N-linoleoyl taurine and PE(O-16:0/20:5(5Z), 8Z, 11Z, 14Z, 17Z). Conversely, RES treatment increased the levels of eight metabolites, including pantothenic acid, homovanillic acid, and S-(formylmethyl)glutathione, and reduced seven metabolites, including lysoPE(20:4(8Z,11Z,14Z,17Z)/0:0) and 13-cis-retinoic acid, etc., in comparison with the LPS group. Moreover, RES treatment alleviated the negative effects of LPS on intestinal microbes by reducing, for instance, the relative abundance of Bacteroidetes and Alistipes, and increasing the relative abundance of Lactobacillus. These results suggest that RES has great potential for preventing in-flammation.
format	article
author	Sujuan Ding Hongmei Jiang Jun Fang Gang Liu
author_facet	Sujuan Ding Hongmei Jiang Jun Fang Gang Liu
author_sort	Sujuan Ding
title	Regulatory Effect of Resveratrol on Inflammation Induced by Lipopolysaccharides via Reprograming Intestinal Microbes and Ameliorating Serum Metabolism Profiles
title_short	Regulatory Effect of Resveratrol on Inflammation Induced by Lipopolysaccharides via Reprograming Intestinal Microbes and Ameliorating Serum Metabolism Profiles
title_full	Regulatory Effect of Resveratrol on Inflammation Induced by Lipopolysaccharides via Reprograming Intestinal Microbes and Ameliorating Serum Metabolism Profiles
title_fullStr	Regulatory Effect of Resveratrol on Inflammation Induced by Lipopolysaccharides via Reprograming Intestinal Microbes and Ameliorating Serum Metabolism Profiles
title_full_unstemmed	Regulatory Effect of Resveratrol on Inflammation Induced by Lipopolysaccharides via Reprograming Intestinal Microbes and Ameliorating Serum Metabolism Profiles
title_sort	regulatory effect of resveratrol on inflammation induced by lipopolysaccharides via reprograming intestinal microbes and ameliorating serum metabolism profiles
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c137a28cb9014411b1d9b3a741ef485f
work_keys_str_mv	AT sujuanding regulatoryeffectofresveratroloninflammationinducedbylipopolysaccharidesviareprogramingintestinalmicrobesandamelioratingserummetabolismprofiles AT hongmeijiang regulatoryeffectofresveratroloninflammationinducedbylipopolysaccharidesviareprogramingintestinalmicrobesandamelioratingserummetabolismprofiles AT junfang regulatoryeffectofresveratroloninflammationinducedbylipopolysaccharidesviareprogramingintestinalmicrobesandamelioratingserummetabolismprofiles AT gangliu regulatoryeffectofresveratroloninflammationinducedbylipopolysaccharidesviareprogramingintestinalmicrobesandamelioratingserummetabolismprofiles
_version_	1718428640910245888

Regulatory Effect of Resveratrol on Inflammation Induced by Lipopolysaccharides via Reprograming Intestinal Microbes and Ameliorating Serum Metabolism Profiles

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