The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells

Human pluripotent stem cells (hPSC) are known to acquire chromosomal abnormalities, which range from point mutations to large copy number changes, including full chromosome aneuploidy. These aberrations have a wide-ranging influence on the state of cells, in both the undifferentiated and differentia...

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Autores principales:	Alexander Keller, Claudia Spits
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pluripotent stem cells embryonic stem cells induced pluripotent stem cells genomic instability differentiation clinical translation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c1395ae971c647e58b863346787b5d7c
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spelling	oai:doaj.org-article:c1395ae971c647e58b863346787b5d7c2021-11-25T17:13:14ZThe Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells10.3390/cells101132462073-4409https://doaj.org/article/c1395ae971c647e58b863346787b5d7c2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3246https://doaj.org/toc/2073-4409Human pluripotent stem cells (hPSC) are known to acquire chromosomal abnormalities, which range from point mutations to large copy number changes, including full chromosome aneuploidy. These aberrations have a wide-ranging influence on the state of cells, in both the undifferentiated and differentiated state. Currently, very little is known on how these abnormalities will impact the clinical translation of hPSC, and particularly their potential to prime cells for oncogenic transformation. A further complication is that many of these abnormalities exist in a mosaic state in culture, which complicates their detection with conventional karyotyping methods. In this review we discuss current knowledge on how these aberrations influence the cell state and how this may impact the future of research and the cells’ clinical potential.Alexander KellerClaudia SpitsMDPI AGarticlepluripotent stem cellsembryonic stem cellsinduced pluripotent stem cellsgenomic instabilitydifferentiationclinical translationBiology (General)QH301-705.5ENCells, Vol 10, Iss 3246, p 3246 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pluripotent stem cells embryonic stem cells induced pluripotent stem cells genomic instability differentiation clinical translation Biology (General) QH301-705.5
spellingShingle	pluripotent stem cells embryonic stem cells induced pluripotent stem cells genomic instability differentiation clinical translation Biology (General) QH301-705.5 Alexander Keller Claudia Spits The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells
description	Human pluripotent stem cells (hPSC) are known to acquire chromosomal abnormalities, which range from point mutations to large copy number changes, including full chromosome aneuploidy. These aberrations have a wide-ranging influence on the state of cells, in both the undifferentiated and differentiated state. Currently, very little is known on how these abnormalities will impact the clinical translation of hPSC, and particularly their potential to prime cells for oncogenic transformation. A further complication is that many of these abnormalities exist in a mosaic state in culture, which complicates their detection with conventional karyotyping methods. In this review we discuss current knowledge on how these aberrations influence the cell state and how this may impact the future of research and the cells’ clinical potential.
format	article
author	Alexander Keller Claudia Spits
author_facet	Alexander Keller Claudia Spits
author_sort	Alexander Keller
title	The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells
title_short	The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells
title_full	The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells
title_fullStr	The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells
title_full_unstemmed	The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells
title_sort	impact of acquired genetic abnormalities on the clinical translation of human pluripotent stem cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c1395ae971c647e58b863346787b5d7c
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The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells

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