Host Mesothelin Expression Increases Ovarian Cancer Metastasis in the Peritoneal Microenvironment

Host Mesothelin Expression Increases Ovarian Cancer Metastasis in the Peritoneal Microenvironment

Mesothelin (MSLN), a glycoprotein normally expressed by mesothelial cells, is overexpressed in ovarian cancer (OvCa) suggesting a role in tumor progression, although the biological function is not fully understood. OvCa has a high mortality rate due to diagnosis at advanced stage disease with intrap...

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Bibliographic Details
Main Authors: Tyvette S. Hilliard, Brooke Kowalski, Kyle Iwamoto, Elizabeth A. Agadi, Yueying Liu, Jing Yang, Marwa Asem, Yuliya Klymenko, Jeff Johnson, Zonggao Shi, Gifty Marfowaa, Madeleine G. Yemc, Phillip Petrasko, M. Sharon Stack
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
ovarian cancer
metastasis
mesothelium
mesothelin
cell adhesion
collagen
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/c13afbf1f05f4c64aad9f7c5b4e9fc4f
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