Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress

Abstract The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation, stress response, and other processes...

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Autores principales: Alexander G. Stepchenko, Tatiana N. Portseva, Ivan A. Glukhov, Alina P. Kotnova, Bella M. Lyanova, Sofia G. Georgieva, Elizaveta V. Pankratova
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:c13c9db2f4e44f64b2fae23a9f111aaa2021-12-02T15:15:05ZPrimate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress10.1038/s41598-021-98323-y2045-2322https://doaj.org/article/c13c9db2f4e44f64b2fae23a9f111aaa2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98323-yhttps://doaj.org/toc/2045-2322Abstract The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation, stress response, and other processes. We have demonstrated that the Tigger2 transposon insertion into the POU2F1 gene which occurred in the primate lineage led to the formation of an additional exon (designated the Z-exon). Z-exon-containing primate-specific Oct-1Z transcript includes a short upstream ORF (uORF) located at its 5’-end and the main ORF encoding the Oct-1Z protein isoform (Pou2F1 isoform 3, P14859-3), which differs from other Oct-1 isoforms by its N-terminal peptide. The Oct-1Z-encoding transcript is expressed mainly in human brain cortex. Under normal conditions, the translation of the ORF coding for the Oct-1Z isoform is repressed by uORF. Under various stress conditions, uORF enables a strong increase in the translation of the Oct-1Z-encoding ORF. Increased Oct-1Z expression levels in differentiating human neuroblasts activate genes controlling stress response, neural cell differentiation, brain formation, and organogenesis. We have shown that the Oct-1Z isoform of the POU2F1/Oct-1 transcription factor is an example of a primate-specific genomic element contributing to brain development and cellular stress defense.Alexander G. StepchenkoTatiana N. PortsevaIvan A. GlukhovAlina P. KotnovaBella M. LyanovaSofia G. GeorgievaElizaveta V. PankratovaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Alexander G. Stepchenko
Tatiana N. Portseva
Ivan A. Glukhov
Alina P. Kotnova
Bella M. Lyanova
Sofia G. Georgieva
Elizaveta V. Pankratova
Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress
description Abstract The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation, stress response, and other processes. We have demonstrated that the Tigger2 transposon insertion into the POU2F1 gene which occurred in the primate lineage led to the formation of an additional exon (designated the Z-exon). Z-exon-containing primate-specific Oct-1Z transcript includes a short upstream ORF (uORF) located at its 5’-end and the main ORF encoding the Oct-1Z protein isoform (Pou2F1 isoform 3, P14859-3), which differs from other Oct-1 isoforms by its N-terminal peptide. The Oct-1Z-encoding transcript is expressed mainly in human brain cortex. Under normal conditions, the translation of the ORF coding for the Oct-1Z isoform is repressed by uORF. Under various stress conditions, uORF enables a strong increase in the translation of the Oct-1Z-encoding ORF. Increased Oct-1Z expression levels in differentiating human neuroblasts activate genes controlling stress response, neural cell differentiation, brain formation, and organogenesis. We have shown that the Oct-1Z isoform of the POU2F1/Oct-1 transcription factor is an example of a primate-specific genomic element contributing to brain development and cellular stress defense.
format article
author Alexander G. Stepchenko
Tatiana N. Portseva
Ivan A. Glukhov
Alina P. Kotnova
Bella M. Lyanova
Sofia G. Georgieva
Elizaveta V. Pankratova
author_facet Alexander G. Stepchenko
Tatiana N. Portseva
Ivan A. Glukhov
Alina P. Kotnova
Bella M. Lyanova
Sofia G. Georgieva
Elizaveta V. Pankratova
author_sort Alexander G. Stepchenko
title Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress
title_short Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress
title_full Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress
title_fullStr Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress
title_full_unstemmed Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress
title_sort primate-specific stress-induced transcription factor pou2f1z protects human neuronal cells from stress
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c13c9db2f4e44f64b2fae23a9f111aaa
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