Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress

Abstract The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation, stress response, and other processes...

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Autores principales:	Alexander G. Stepchenko, Tatiana N. Portseva, Ivan A. Glukhov, Alina P. Kotnova, Bella M. Lyanova, Sofia G. Georgieva, Elizaveta V. Pankratova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c13c9db2f4e44f64b2fae23a9f111aaa
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spelling	oai:doaj.org-article:c13c9db2f4e44f64b2fae23a9f111aaa2021-12-02T15:15:05ZPrimate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress10.1038/s41598-021-98323-y2045-2322https://doaj.org/article/c13c9db2f4e44f64b2fae23a9f111aaa2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98323-yhttps://doaj.org/toc/2045-2322Abstract The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation, stress response, and other processes. We have demonstrated that the Tigger2 transposon insertion into the POU2F1 gene which occurred in the primate lineage led to the formation of an additional exon (designated the Z-exon). Z-exon-containing primate-specific Oct-1Z transcript includes a short upstream ORF (uORF) located at its 5’-end and the main ORF encoding the Oct-1Z protein isoform (Pou2F1 isoform 3, P14859-3), which differs from other Oct-1 isoforms by its N-terminal peptide. The Oct-1Z-encoding transcript is expressed mainly in human brain cortex. Under normal conditions, the translation of the ORF coding for the Oct-1Z isoform is repressed by uORF. Under various stress conditions, uORF enables a strong increase in the translation of the Oct-1Z-encoding ORF. Increased Oct-1Z expression levels in differentiating human neuroblasts activate genes controlling stress response, neural cell differentiation, brain formation, and organogenesis. We have shown that the Oct-1Z isoform of the POU2F1/Oct-1 transcription factor is an example of a primate-specific genomic element contributing to brain development and cellular stress defense.Alexander G. StepchenkoTatiana N. PortsevaIvan A. GlukhovAlina P. KotnovaBella M. LyanovaSofia G. GeorgievaElizaveta V. PankratovaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander G. Stepchenko Tatiana N. Portseva Ivan A. Glukhov Alina P. Kotnova Bella M. Lyanova Sofia G. Georgieva Elizaveta V. Pankratova Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress
description	Abstract The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation, stress response, and other processes. We have demonstrated that the Tigger2 transposon insertion into the POU2F1 gene which occurred in the primate lineage led to the formation of an additional exon (designated the Z-exon). Z-exon-containing primate-specific Oct-1Z transcript includes a short upstream ORF (uORF) located at its 5’-end and the main ORF encoding the Oct-1Z protein isoform (Pou2F1 isoform 3, P14859-3), which differs from other Oct-1 isoforms by its N-terminal peptide. The Oct-1Z-encoding transcript is expressed mainly in human brain cortex. Under normal conditions, the translation of the ORF coding for the Oct-1Z isoform is repressed by uORF. Under various stress conditions, uORF enables a strong increase in the translation of the Oct-1Z-encoding ORF. Increased Oct-1Z expression levels in differentiating human neuroblasts activate genes controlling stress response, neural cell differentiation, brain formation, and organogenesis. We have shown that the Oct-1Z isoform of the POU2F1/Oct-1 transcription factor is an example of a primate-specific genomic element contributing to brain development and cellular stress defense.
format	article
author	Alexander G. Stepchenko Tatiana N. Portseva Ivan A. Glukhov Alina P. Kotnova Bella M. Lyanova Sofia G. Georgieva Elizaveta V. Pankratova
author_facet	Alexander G. Stepchenko Tatiana N. Portseva Ivan A. Glukhov Alina P. Kotnova Bella M. Lyanova Sofia G. Georgieva Elizaveta V. Pankratova
author_sort	Alexander G. Stepchenko
title	Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress
title_short	Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress
title_full	Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress
title_fullStr	Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress
title_full_unstemmed	Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress
title_sort	primate-specific stress-induced transcription factor pou2f1z protects human neuronal cells from stress
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c13c9db2f4e44f64b2fae23a9f111aaa
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Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress

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