Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor

Asthma is characterized by abnormal airway hyperresponsiveness. Here the authors identify BPIFA1 as a factor secreted by airway epithelial cells, and show that it regulates contractility of airway smooth muscle cells by binding to and regulating the Orai1 Ca2+channel.

Guardado en:

Detalles Bibliográficos
Autores principales:	Tongde Wu, Julianne Huang, Patrick J. Moore, Michael S. Little, William G. Walton, Robert C. Fellner, Neil E. Alexis, Y. Peter Di, Matthew R. Redinbo, Stephen L. Tilley, Robert Tarran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c13d74cd6193402c97012e807c2d9c19
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c13d74cd6193402c97012e807c2d9c19
record_format	dspace
spelling	oai:doaj.org-article:c13d74cd6193402c97012e807c2d9c192021-12-02T14:42:09ZIdentification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor10.1038/ncomms141182041-1723https://doaj.org/article/c13d74cd6193402c97012e807c2d9c192017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14118https://doaj.org/toc/2041-1723Asthma is characterized by abnormal airway hyperresponsiveness. Here the authors identify BPIFA1 as a factor secreted by airway epithelial cells, and show that it regulates contractility of airway smooth muscle cells by binding to and regulating the Orai1 Ca2+channel.Tongde WuJulianne HuangPatrick J. MooreMichael S. LittleWilliam G. WaltonRobert C. FellnerNeil E. AlexisY. Peter DiMatthew R. RedinboStephen L. TilleyRobert TarranNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tongde Wu Julianne Huang Patrick J. Moore Michael S. Little William G. Walton Robert C. Fellner Neil E. Alexis Y. Peter Di Matthew R. Redinbo Stephen L. Tilley Robert Tarran Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor
description	Asthma is characterized by abnormal airway hyperresponsiveness. Here the authors identify BPIFA1 as a factor secreted by airway epithelial cells, and show that it regulates contractility of airway smooth muscle cells by binding to and regulating the Orai1 Ca2+channel.
format	article
author	Tongde Wu Julianne Huang Patrick J. Moore Michael S. Little William G. Walton Robert C. Fellner Neil E. Alexis Y. Peter Di Matthew R. Redinbo Stephen L. Tilley Robert Tarran
author_facet	Tongde Wu Julianne Huang Patrick J. Moore Michael S. Little William G. Walton Robert C. Fellner Neil E. Alexis Y. Peter Di Matthew R. Redinbo Stephen L. Tilley Robert Tarran
author_sort	Tongde Wu
title	Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor
title_short	Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor
title_full	Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor
title_fullStr	Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor
title_full_unstemmed	Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor
title_sort	identification of bpifa1/splunc1 as an epithelium-derived smooth muscle relaxing factor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c13d74cd6193402c97012e807c2d9c19
work_keys_str_mv	AT tongdewu identificationofbpifa1splunc1asanepitheliumderivedsmoothmusclerelaxingfactor AT juliannehuang identificationofbpifa1splunc1asanepitheliumderivedsmoothmusclerelaxingfactor AT patrickjmoore identificationofbpifa1splunc1asanepitheliumderivedsmoothmusclerelaxingfactor AT michaelslittle identificationofbpifa1splunc1asanepitheliumderivedsmoothmusclerelaxingfactor AT williamgwalton identificationofbpifa1splunc1asanepitheliumderivedsmoothmusclerelaxingfactor AT robertcfellner identificationofbpifa1splunc1asanepitheliumderivedsmoothmusclerelaxingfactor AT neilealexis identificationofbpifa1splunc1asanepitheliumderivedsmoothmusclerelaxingfactor AT ypeterdi identificationofbpifa1splunc1asanepitheliumderivedsmoothmusclerelaxingfactor AT matthewrredinbo identificationofbpifa1splunc1asanepitheliumderivedsmoothmusclerelaxingfactor AT stephenltilley identificationofbpifa1splunc1asanepitheliumderivedsmoothmusclerelaxingfactor AT roberttarran identificationofbpifa1splunc1asanepitheliumderivedsmoothmusclerelaxingfactor
_version_	1718389776443244544

Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor

Ejemplares similares