FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression

Puan and San Luis et al. find that FUT6, encoding a fucosyltransferase, is required for the “rolling” behavior of certain white blood cells that enables them to move from blood vessels to tissues. They show that FUT6 deficiency leads to a loss of the tetrasaccharide sLex on the surface of basophils,...

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Autores principales:	Kia Joo Puan, Boris San Luis, Nurhashikin Yusof, Dilip Kumar, Anand Kumar Andiappan, Wendy Lee, Samanta Cajic, Dragana Vuckovic, Jing De Chan, Tobias Döllner, Han Wei Hou, Yunxuan Jiang, Chao Tian, the 23andMe Research Team, Erdmann Rapp, Michael Poidinger, De Yun Wang, Nicole Soranzo, Bernett Lee, Olaf Rötzschke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c143d737821c4b528b01c70d7893f2f4
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spelling	oai:doaj.org-article:c143d737821c4b528b01c70d7893f2f42021-12-02T16:10:32ZFUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression10.1038/s42003-021-02295-82399-3642https://doaj.org/article/c143d737821c4b528b01c70d7893f2f42021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02295-8https://doaj.org/toc/2399-3642Puan and San Luis et al. find that FUT6, encoding a fucosyltransferase, is required for the “rolling” behavior of certain white blood cells that enables them to move from blood vessels to tissues. They show that FUT6 deficiency leads to a loss of the tetrasaccharide sLex on the surface of basophils, resulting in cells that are less sticky and therefore less able to form the necessary adhesions for exiting the blood vessel to drive the allergic reaction.Kia Joo PuanBoris San LuisNurhashikin YusofDilip KumarAnand Kumar AndiappanWendy LeeSamanta CajicDragana VuckovicJing De ChanTobias DöllnerHan Wei HouYunxuan JiangChao Tianthe 23andMe Research TeamErdmann RappMichael PoidingerDe Yun WangNicole SoranzoBernett LeeOlaf RötzschkeNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Kia Joo Puan Boris San Luis Nurhashikin Yusof Dilip Kumar Anand Kumar Andiappan Wendy Lee Samanta Cajic Dragana Vuckovic Jing De Chan Tobias Döllner Han Wei Hou Yunxuan Jiang Chao Tian the 23andMe Research Team Erdmann Rapp Michael Poidinger De Yun Wang Nicole Soranzo Bernett Lee Olaf Rötzschke FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression
description	Puan and San Luis et al. find that FUT6, encoding a fucosyltransferase, is required for the “rolling” behavior of certain white blood cells that enables them to move from blood vessels to tissues. They show that FUT6 deficiency leads to a loss of the tetrasaccharide sLex on the surface of basophils, resulting in cells that are less sticky and therefore less able to form the necessary adhesions for exiting the blood vessel to drive the allergic reaction.
format	article
author	Kia Joo Puan Boris San Luis Nurhashikin Yusof Dilip Kumar Anand Kumar Andiappan Wendy Lee Samanta Cajic Dragana Vuckovic Jing De Chan Tobias Döllner Han Wei Hou Yunxuan Jiang Chao Tian the 23andMe Research Team Erdmann Rapp Michael Poidinger De Yun Wang Nicole Soranzo Bernett Lee Olaf Rötzschke
author_facet	Kia Joo Puan Boris San Luis Nurhashikin Yusof Dilip Kumar Anand Kumar Andiappan Wendy Lee Samanta Cajic Dragana Vuckovic Jing De Chan Tobias Döllner Han Wei Hou Yunxuan Jiang Chao Tian the 23andMe Research Team Erdmann Rapp Michael Poidinger De Yun Wang Nicole Soranzo Bernett Lee Olaf Rötzschke
author_sort	Kia Joo Puan
title	FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression
title_short	FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression
title_full	FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression
title_fullStr	FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression
title_full_unstemmed	FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression
title_sort	fut6 deficiency compromises basophil function by selectively abrogating their sialyl-lewis x expression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c143d737821c4b528b01c70d7893f2f4
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FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression

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