Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report
Remdesivir is under evaluation for treatment of COVID-19 in clinical trials. Here, the authors report results of remdesivir treatment in a patient with COVID-19 and the genetic antibody deficiency XLA. They show a temporally correlated clinical and virological response, suggesting that remdesivir ca...
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Nature Portfolio
2020
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oai:doaj.org-article:c14cbd11e914499b8bdaf50363c878052021-12-02T14:16:14ZTreatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report10.1038/s41467-020-19761-22041-1723https://doaj.org/article/c14cbd11e914499b8bdaf50363c878052020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19761-2https://doaj.org/toc/2041-1723Remdesivir is under evaluation for treatment of COVID-19 in clinical trials. Here, the authors report results of remdesivir treatment in a patient with COVID-19 and the genetic antibody deficiency XLA. They show a temporally correlated clinical and virological response, suggesting that remdesivir can reduce SARS-CoV-2 replication in patients.Matthew S. BucklandJames B. GallowayCaoimhe Nic FhogartaighLuke MeredithNicholas M. ProvineStuart BloorAne OgbeWioleta M. ZelekAnna SmielewskaAnna YakovlevaTiffeney MannLaura BergamaschiLorinda TurnerFrederica MesciaErik J. M. ToonenCarl-Philipp HacksteinHossain Delowar AktherVinicius Adriano VieiraLourdes Ceron-GutierrezJimstan PeriselnerisSorena Kiani-AlikhanSofia GrigoriadouDevan VaghelaSara E. LearM. Estée TörökWilliam L. HamiltonJoanne StocktonJosh QuickPeter NelsonMichael HunterTanya I. CoulterLisa DevlinCITIID-NIHR COVID-19 BioResource CollaborationMRC-Toxicology Unit COVID-19 ConsortiumJohn R. BradleyKenneth G. C. SmithWillem H. OuwehandLise EstcourtHeli HarvalaDavid J. RobertsIan B. WilkinsonNick ScreatonNicholas LomanRainer DoffingerPaul A. LyonsB. Paul MorganIan G. GoodfellowPaul KlenermanPaul J. LehnerNicholas J. MathesonJames E. D. ThaventhiranNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Matthew S. Buckland James B. Galloway Caoimhe Nic Fhogartaigh Luke Meredith Nicholas M. Provine Stuart Bloor Ane Ogbe Wioleta M. Zelek Anna Smielewska Anna Yakovleva Tiffeney Mann Laura Bergamaschi Lorinda Turner Frederica Mescia Erik J. M. Toonen Carl-Philipp Hackstein Hossain Delowar Akther Vinicius Adriano Vieira Lourdes Ceron-Gutierrez Jimstan Periselneris Sorena Kiani-Alikhan Sofia Grigoriadou Devan Vaghela Sara E. Lear M. Estée Török William L. Hamilton Joanne Stockton Josh Quick Peter Nelson Michael Hunter Tanya I. Coulter Lisa Devlin CITIID-NIHR COVID-19 BioResource Collaboration MRC-Toxicology Unit COVID-19 Consortium John R. Bradley Kenneth G. C. Smith Willem H. Ouwehand Lise Estcourt Heli Harvala David J. Roberts Ian B. Wilkinson Nick Screaton Nicholas Loman Rainer Doffinger Paul A. Lyons B. Paul Morgan Ian G. Goodfellow Paul Klenerman Paul J. Lehner Nicholas J. Matheson James E. D. Thaventhiran Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report |
| description |
Remdesivir is under evaluation for treatment of COVID-19 in clinical trials. Here, the authors report results of remdesivir treatment in a patient with COVID-19 and the genetic antibody deficiency XLA. They show a temporally correlated clinical and virological response, suggesting that remdesivir can reduce SARS-CoV-2 replication in patients. |
| format |
article |
| author |
Matthew S. Buckland James B. Galloway Caoimhe Nic Fhogartaigh Luke Meredith Nicholas M. Provine Stuart Bloor Ane Ogbe Wioleta M. Zelek Anna Smielewska Anna Yakovleva Tiffeney Mann Laura Bergamaschi Lorinda Turner Frederica Mescia Erik J. M. Toonen Carl-Philipp Hackstein Hossain Delowar Akther Vinicius Adriano Vieira Lourdes Ceron-Gutierrez Jimstan Periselneris Sorena Kiani-Alikhan Sofia Grigoriadou Devan Vaghela Sara E. Lear M. Estée Török William L. Hamilton Joanne Stockton Josh Quick Peter Nelson Michael Hunter Tanya I. Coulter Lisa Devlin CITIID-NIHR COVID-19 BioResource Collaboration MRC-Toxicology Unit COVID-19 Consortium John R. Bradley Kenneth G. C. Smith Willem H. Ouwehand Lise Estcourt Heli Harvala David J. Roberts Ian B. Wilkinson Nick Screaton Nicholas Loman Rainer Doffinger Paul A. Lyons B. Paul Morgan Ian G. Goodfellow Paul Klenerman Paul J. Lehner Nicholas J. Matheson James E. D. Thaventhiran |
| author_facet |
Matthew S. Buckland James B. Galloway Caoimhe Nic Fhogartaigh Luke Meredith Nicholas M. Provine Stuart Bloor Ane Ogbe Wioleta M. Zelek Anna Smielewska Anna Yakovleva Tiffeney Mann Laura Bergamaschi Lorinda Turner Frederica Mescia Erik J. M. Toonen Carl-Philipp Hackstein Hossain Delowar Akther Vinicius Adriano Vieira Lourdes Ceron-Gutierrez Jimstan Periselneris Sorena Kiani-Alikhan Sofia Grigoriadou Devan Vaghela Sara E. Lear M. Estée Török William L. Hamilton Joanne Stockton Josh Quick Peter Nelson Michael Hunter Tanya I. Coulter Lisa Devlin CITIID-NIHR COVID-19 BioResource Collaboration MRC-Toxicology Unit COVID-19 Consortium John R. Bradley Kenneth G. C. Smith Willem H. Ouwehand Lise Estcourt Heli Harvala David J. Roberts Ian B. Wilkinson Nick Screaton Nicholas Loman Rainer Doffinger Paul A. Lyons B. Paul Morgan Ian G. Goodfellow Paul Klenerman Paul J. Lehner Nicholas J. Matheson James E. D. Thaventhiran |
| author_sort |
Matthew S. Buckland |
| title |
Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report |
| title_short |
Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report |
| title_full |
Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report |
| title_fullStr |
Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report |
| title_full_unstemmed |
Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report |
| title_sort |
treatment of covid-19 with remdesivir in the absence of humoral immunity: a case report |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/c14cbd11e914499b8bdaf50363c87805 |
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