Discovery of a drug candidate for GLIS3-associated diabetes

Discovery of a drug candidate for GLIS3-associated diabetes

GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes. Here, the authors generate mono-hormonal glucose-responding pancreatic β-like cells in vitro and through a screen identify a drug that rescues pancreatic β-like cell death in GLIS3 mutants by inhibiting the abnormally activat...

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Autores principales: Sadaf Amin, Brandoch Cook, Ting Zhou, Zaniar Ghazizadeh, Raphael Lis, Tuo Zhang, Mona Khalaj, Miguel Crespo, Manuradhi Perera, Jenny Zhaoying Xiang, Zengrong Zhu, Mark Tomishima, Chengyang Liu, Ali Naji, Todd Evans, Danwei Huangfu, Shuibing Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/c14e49f0fd174b1ebce0f8854fb56b94
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spelling oai:doaj.org-article:c14e49f0fd174b1ebce0f8854fb56b942021-12-02T14:39:25ZDiscovery of a drug candidate for GLIS3-associated diabetes10.1038/s41467-018-04918-x2041-1723https://doaj.org/article/c14e49f0fd174b1ebce0f8854fb56b942018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04918-xhttps://doaj.org/toc/2041-1723GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes. Here, the authors generate mono-hormonal glucose-responding pancreatic β-like cells in vitro and through a screen identify a drug that rescues pancreatic β-like cell death in GLIS3 mutants by inhibiting the abnormally activated TGFβ pathway.Sadaf AminBrandoch CookTing ZhouZaniar GhazizadehRaphael LisTuo ZhangMona KhalajMiguel CrespoManuradhi PereraJenny Zhaoying XiangZengrong ZhuMark TomishimaChengyang LiuAli NajiTodd EvansDanwei HuangfuShuibing ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sadaf Amin
Brandoch Cook
Ting Zhou
Zaniar Ghazizadeh
Raphael Lis
Tuo Zhang
Mona Khalaj
Miguel Crespo
Manuradhi Perera
Jenny Zhaoying Xiang
Zengrong Zhu
Mark Tomishima
Chengyang Liu
Ali Naji
Todd Evans
Danwei Huangfu
Shuibing Chen
Discovery of a drug candidate for GLIS3-associated diabetes
description GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes. Here, the authors generate mono-hormonal glucose-responding pancreatic β-like cells in vitro and through a screen identify a drug that rescues pancreatic β-like cell death in GLIS3 mutants by inhibiting the abnormally activated TGFβ pathway.
format article
author Sadaf Amin
Brandoch Cook
Ting Zhou
Zaniar Ghazizadeh
Raphael Lis
Tuo Zhang
Mona Khalaj
Miguel Crespo
Manuradhi Perera
Jenny Zhaoying Xiang
Zengrong Zhu
Mark Tomishima
Chengyang Liu
Ali Naji
Todd Evans
Danwei Huangfu
Shuibing Chen
author_facet Sadaf Amin
Brandoch Cook
Ting Zhou
Zaniar Ghazizadeh
Raphael Lis
Tuo Zhang
Mona Khalaj
Miguel Crespo
Manuradhi Perera
Jenny Zhaoying Xiang
Zengrong Zhu
Mark Tomishima
Chengyang Liu
Ali Naji
Todd Evans
Danwei Huangfu
Shuibing Chen
author_sort Sadaf Amin
title Discovery of a drug candidate for GLIS3-associated diabetes
title_short Discovery of a drug candidate for GLIS3-associated diabetes
title_full Discovery of a drug candidate for GLIS3-associated diabetes
title_fullStr Discovery of a drug candidate for GLIS3-associated diabetes
title_full_unstemmed Discovery of a drug candidate for GLIS3-associated diabetes
title_sort discovery of a drug candidate for glis3-associated diabetes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/c14e49f0fd174b1ebce0f8854fb56b94
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