Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine–Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2

Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine–Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2

ABSTRACT The Norovirus genus contains important human pathogens, but the role of host pathways in norovirus replication is largely unknown. Murine noroviruses provide the opportunity to study norovirus replication in cell culture and in small animals. The human norovirus nonstructural protein NS1/2...

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Autores principales: Broc T. McCune, Wei Tang, Jia Lu, James B. Eaglesham, Lucy Thorne, Anne E. Mayer, Emily Condiff, Timothy J. Nice, Ian Goodfellow, Andrzej M. Krezel, Herbert W. Virgin
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
noroviruses
plus-strand RNA virus
protein structure-function
reverse genetic analysis
viral replication
virus-host interactions
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/c14f5cf474dd4ad49e80a9614b687337
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