Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer
Abstract Stimulator of interferon genes (STING) controlled innate immune pathway is essential for host defense against pathogenic infection and effective anti-tumor adaptive immunity initiation. Although macrophages transformed across diverse phenotypes play crucial roles in anti-tumor immune respon...
Guardado en:
Autores principales: | Jinglu Yu, Haibin Deng, Zhenye Xu |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/c14f5d14618243e1802b773ca6609d5a |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment
por: Steven Lohard, et al.
Publicado: (2020) -
Polyphyllin I suppresses human osteosarcoma growth by inactivation of Wnt/β-catenin pathway in vitro and in vivo
por: Junli Chang, et al.
Publicado: (2017) -
Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging
por: Michael F. Cuccarese, et al.
Publicado: (2017) -
STING-dependent sensing of self-DNA drives silica-induced lung inflammation
por: Sulayman Benmerzoug, et al.
Publicado: (2018) -
Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit
por: Theodora Katopodi, et al.
Publicado: (2021)