The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon

Background. The treatment of purulent-inflammatory processes of soft tissues remains today an area of surgery that is not given enough attention by specialists of both inpatient and outpatient levels, with many unresolved problems. Of particular importance in the pathogenesis of purulent-septic proc...

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Autores principales:	E. A. Tseimakh, V. Yu. Zinchenko
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	cryoplasma-anti-enzyme complex phlegmon thrombohemorrhagic syndrome sepsis microcirculation disorder Science Q
Acceso en línea:	https://doaj.org/article/c15644f5d56a475abba36e7a693ec56d
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spelling	oai:doaj.org-article:c15644f5d56a475abba36e7a693ec56d2021-11-23T06:14:47ZThe importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon2541-94202587-959610.29413/ABS.2021-6.5.20https://doaj.org/article/c15644f5d56a475abba36e7a693ec56d2021-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/3051https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. The treatment of purulent-inflammatory processes of soft tissues remains today an area of surgery that is not given enough attention by specialists of both inpatient and outpatient levels, with many unresolved problems. Of particular importance in the pathogenesis of purulent-septic processes are the emerging microcirculation disorders due to the formation of micro-clots. An important point that aggravates the course of the disease is the development of thrombohemorrhagic syndrome. As a result, even with a variety of antibacterial drugs and the ыavailability of new treatment methods, it is often not possible to achieve positive results in the treatment of this heavy contingent of patients.Aim: to improve the effectiveness of complex therapy of patients with extensive soft tissue phlegmon by relieving thrombohemorrhagic syndrome.Materials and methods. Cryoplasma-anti-enzyme therapy in the composition of complex treatment was received by 59 (48.8 %) patients of the main group, 62 (51.2 %) patients of the comparison group received only the generally accepted treatment. In each group, there are three variants of the course of the disease – moderate, severe and septic.Results. The analysis of the clinical course of the disease showed that in patients of the first group, wounds were cleared of necrotic masses and purulent discharge with filling them with healthy granulation tissue 5.3 days faster than in the second group (p˂0.001). The number of deaths decreased – 11.9 % in the first group against 27.4 % in the second group (p˂ 0.001). The number of deaths decreased – 11.9 % in the first group against 27.4 % in the second group (p˂ 0.001). The proportion of thrombotic and thromboembolic causes of death in the first group (14.3 %) was lower than in the second (17.7 %) (p˂ 0.05).Conclusion. The use of cryoplasma-anti-enzyme therapy as part of complex treatment contributed to the effective relief of thrombohemorrhagic syndrome, the elimination of microcirculatory disorders, which allowed performing plastic closure of a wound defect 1.6 times faster, prevented the progression of multiple organ failure, and contributed to a reduction in mortality.E. A. TseimakhV. Yu. ZinchenkoScientific Сentre for Family Health and Human Reproduction Problemsarticlecryoplasma-anti-enzyme complexphlegmonthrombohemorrhagic syndromesepsismicrocirculation disorderScienceQRUActa Biomedica Scientifica, Vol 6, Iss 5, Pp 212-221 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	cryoplasma-anti-enzyme complex phlegmon thrombohemorrhagic syndrome sepsis microcirculation disorder Science Q
spellingShingle	cryoplasma-anti-enzyme complex phlegmon thrombohemorrhagic syndrome sepsis microcirculation disorder Science Q E. A. Tseimakh V. Yu. Zinchenko The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon
description	Background. The treatment of purulent-inflammatory processes of soft tissues remains today an area of surgery that is not given enough attention by specialists of both inpatient and outpatient levels, with many unresolved problems. Of particular importance in the pathogenesis of purulent-septic processes are the emerging microcirculation disorders due to the formation of micro-clots. An important point that aggravates the course of the disease is the development of thrombohemorrhagic syndrome. As a result, even with a variety of antibacterial drugs and the ыavailability of new treatment methods, it is often not possible to achieve positive results in the treatment of this heavy contingent of patients.Aim: to improve the effectiveness of complex therapy of patients with extensive soft tissue phlegmon by relieving thrombohemorrhagic syndrome.Materials and methods. Cryoplasma-anti-enzyme therapy in the composition of complex treatment was received by 59 (48.8 %) patients of the main group, 62 (51.2 %) patients of the comparison group received only the generally accepted treatment. In each group, there are three variants of the course of the disease – moderate, severe and septic.Results. The analysis of the clinical course of the disease showed that in patients of the first group, wounds were cleared of necrotic masses and purulent discharge with filling them with healthy granulation tissue 5.3 days faster than in the second group (p˂0.001). The number of deaths decreased – 11.9 % in the first group against 27.4 % in the second group (p˂ 0.001). The number of deaths decreased – 11.9 % in the first group against 27.4 % in the second group (p˂ 0.001). The proportion of thrombotic and thromboembolic causes of death in the first group (14.3 %) was lower than in the second (17.7 %) (p˂ 0.05).Conclusion. The use of cryoplasma-anti-enzyme therapy as part of complex treatment contributed to the effective relief of thrombohemorrhagic syndrome, the elimination of microcirculatory disorders, which allowed performing plastic closure of a wound defect 1.6 times faster, prevented the progression of multiple organ failure, and contributed to a reduction in mortality.
format	article
author	E. A. Tseimakh V. Yu. Zinchenko
author_facet	E. A. Tseimakh V. Yu. Zinchenko
author_sort	E. A. Tseimakh
title	The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon
title_short	The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon
title_full	The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon
title_fullStr	The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon
title_full_unstemmed	The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon
title_sort	importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/c15644f5d56a475abba36e7a693ec56d
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The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon

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