Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice

Context: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, γ-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system. Objective: We...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Haoyue Yang, Ronge Xing, Song Liu, Huahua Yu, Pengcheng Li
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	gaba thyroid hormone synthesis myocardial preservation anti-hypothyroidism Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c1570dc39df54bf294eb4b304d5a8132
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c1570dc39df54bf294eb4b304d5a8132
record_format	dspace
spelling	oai:doaj.org-article:c1570dc39df54bf294eb4b304d5a81322021-11-17T14:21:55ZAnalysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice1388-02091744-511610.1080/13880209.2018.1563621https://doaj.org/article/c1570dc39df54bf294eb4b304d5a81322019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2018.1563621https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, γ-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system. Objective: We investigated the ability of GABA to ameliorate fluoride-induced thyroid injury in mice, and investigated the mechanism(s) associated with GABA-induced protection. Materials and methods: Adult male Kumning mice (N = 90) were exposed to NaF (50 mg/kg) for 30 days as a model of hypothyroidism. To evaluate the effects of GABA administration, fluoride-exposed mice received either thyroid tablets, or low (25 mg/kg), medium (50 mg/kg) or high (75 mg/kg) concentrations of pure GABA orally for 14 days groups (N = 10 each). The effects of low (50 mg/kg); medium (75 mg/kg) and high (100 mg/kg) concentrations of laboratory-separated GABA were assessed for comparison. Effects on thyroid hormone production, oxidative stress, thyroid function-associated genes, and side-effects during therapy were measured. Results: GABA supplementation in fluoride-exposed mice significantly increased the expression of thyroid TG, TPO, and NIS (P < 0.05), significantly improved the thyroid redox state (P < 0.05), modulated the expression of thyroid function-associated genes, conferred liver metabolic protection, and prevented changes to myocardial morphology, thus reducing side effects. Both pure and laboratory-separated GABA displayed comparative protective effects. Discussion and conclusion: Our findings support the assertion that GABA exerts therapeutic potential in hypothyroidism. The design and use of human GABA trials to improve therapeutic outcomes in hypothyroidism are now warranted.Haoyue YangRonge XingSong LiuHuahua YuPengcheng LiTaylor & Francis Grouparticlegabathyroid hormone synthesismyocardial preservationanti-hypothyroidismTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 28-36 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	gaba thyroid hormone synthesis myocardial preservation anti-hypothyroidism Therapeutics. Pharmacology RM1-950
spellingShingle	gaba thyroid hormone synthesis myocardial preservation anti-hypothyroidism Therapeutics. Pharmacology RM1-950 Haoyue Yang Ronge Xing Song Liu Huahua Yu Pengcheng Li Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice
description	Context: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, γ-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system. Objective: We investigated the ability of GABA to ameliorate fluoride-induced thyroid injury in mice, and investigated the mechanism(s) associated with GABA-induced protection. Materials and methods: Adult male Kumning mice (N = 90) were exposed to NaF (50 mg/kg) for 30 days as a model of hypothyroidism. To evaluate the effects of GABA administration, fluoride-exposed mice received either thyroid tablets, or low (25 mg/kg), medium (50 mg/kg) or high (75 mg/kg) concentrations of pure GABA orally for 14 days groups (N = 10 each). The effects of low (50 mg/kg); medium (75 mg/kg) and high (100 mg/kg) concentrations of laboratory-separated GABA were assessed for comparison. Effects on thyroid hormone production, oxidative stress, thyroid function-associated genes, and side-effects during therapy were measured. Results: GABA supplementation in fluoride-exposed mice significantly increased the expression of thyroid TG, TPO, and NIS (P < 0.05), significantly improved the thyroid redox state (P < 0.05), modulated the expression of thyroid function-associated genes, conferred liver metabolic protection, and prevented changes to myocardial morphology, thus reducing side effects. Both pure and laboratory-separated GABA displayed comparative protective effects. Discussion and conclusion: Our findings support the assertion that GABA exerts therapeutic potential in hypothyroidism. The design and use of human GABA trials to improve therapeutic outcomes in hypothyroidism are now warranted.
format	article
author	Haoyue Yang Ronge Xing Song Liu Huahua Yu Pengcheng Li
author_facet	Haoyue Yang Ronge Xing Song Liu Huahua Yu Pengcheng Li
author_sort	Haoyue Yang
title	Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice
title_short	Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice
title_full	Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice
title_fullStr	Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice
title_full_unstemmed	Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice
title_sort	analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male kunming mice
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/c1570dc39df54bf294eb4b304d5a8132
work_keys_str_mv	AT haoyueyang analysisoftheprotectiveeffectsofgaminobutyricacidduringfluorideinducedhypothyroidisminmalekunmingmice AT rongexing analysisoftheprotectiveeffectsofgaminobutyricacidduringfluorideinducedhypothyroidisminmalekunmingmice AT songliu analysisoftheprotectiveeffectsofgaminobutyricacidduringfluorideinducedhypothyroidisminmalekunmingmice AT huahuayu analysisoftheprotectiveeffectsofgaminobutyricacidduringfluorideinducedhypothyroidisminmalekunmingmice AT pengchengli analysisoftheprotectiveeffectsofgaminobutyricacidduringfluorideinducedhypothyroidisminmalekunmingmice
_version_	1718425507586899968

Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice

Ejemplares similares