Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis

Tetsuya Mutoh, Masaya Nishio, Yukihiro Matsumoto, Kiyomi Arai Department of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAims: The aim of the present study was to evaluate the correlation between matrix &shy;metalloproteinase-9 (MMP-9) and chondroitin...

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Autores principales:	Tetsuya Mutoh, Masaya Nishio, Yukihiro Matsumoto, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c15b69f5b0bd467d89c7a4c013cd245d
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spelling	oai:doaj.org-article:c15b69f5b0bd467d89c7a4c013cd245d2021-12-02T02:30:13ZCorrelation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis1177-54671177-5483https://doaj.org/article/c15b69f5b0bd467d89c7a4c013cd245d2010-07-01T00:00:00Zhttp://www.dovepress.com/correlation-between-the-matrix-metalloproteinase-9-activity-and-chondr-a4875https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Tetsuya Mutoh, Masaya Nishio, Yukihiro Matsumoto, Kiyomi Arai Department of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAims: The aim of the present study was to evaluate the correlation between matrix &shy;metalloproteinase-9 (MMP-9) and chondroitin sulfate (CS) concentrations in human tear fluid following laser in situ keratomileusis (LASIK).Methods: Twelve eyes from six patients who had no ocular complaints except for &shy;refractive errors, and who had undergone LASIK, were enrolled in this study. We measured the &shy;concentrations of chondroitin 4 sulfate (C4S), chondroitin 6 sulfate (C6S), and MMP-9 activity with an enzyme-linked immunosorbent assay and an enzyme immunocapture activity assay preoperatively and postoperatively on days 1 and 4, week 1, and at 1 and 3 months.Results: Although the preoperative MMP-9 activity and the C4S concentration were highly correlated (r = 0.900; P &lt; 0.001), they were not postoperatively correlated at month 1. Although the preoperative MMP-9 activity and the C6S concentration were highly &shy;correlated (r = 0.885; P &lt; 0.001), they were not postoperatively correlated at either week 1 or months 1 and 3.Conclusions: The correlation appeared to be collapsed by LASIK, and it did not recover to the preoperative score at 3 months post-surgery. Our study indicates that the corneal wound healing was not terminated at 3 months following LASIK.Keywords: preoperative correlation, postoperative correlation, wound healing, refractive errors, human cornea Tetsuya MutohMasaya NishioYukihiro Matsumotoet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 823-828 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Tetsuya Mutoh Masaya Nishio Yukihiro Matsumoto et al Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis
description	Tetsuya Mutoh, Masaya Nishio, Yukihiro Matsumoto, Kiyomi Arai Department of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAims: The aim of the present study was to evaluate the correlation between matrix &shy;metalloproteinase-9 (MMP-9) and chondroitin sulfate (CS) concentrations in human tear fluid following laser in situ keratomileusis (LASIK).Methods: Twelve eyes from six patients who had no ocular complaints except for &shy;refractive errors, and who had undergone LASIK, were enrolled in this study. We measured the &shy;concentrations of chondroitin 4 sulfate (C4S), chondroitin 6 sulfate (C6S), and MMP-9 activity with an enzyme-linked immunosorbent assay and an enzyme immunocapture activity assay preoperatively and postoperatively on days 1 and 4, week 1, and at 1 and 3 months.Results: Although the preoperative MMP-9 activity and the C4S concentration were highly correlated (r = 0.900; P &lt; 0.001), they were not postoperatively correlated at month 1. Although the preoperative MMP-9 activity and the C6S concentration were highly &shy;correlated (r = 0.885; P &lt; 0.001), they were not postoperatively correlated at either week 1 or months 1 and 3.Conclusions: The correlation appeared to be collapsed by LASIK, and it did not recover to the preoperative score at 3 months post-surgery. Our study indicates that the corneal wound healing was not terminated at 3 months following LASIK.Keywords: preoperative correlation, postoperative correlation, wound healing, refractive errors, human cornea
format	article
author	Tetsuya Mutoh Masaya Nishio Yukihiro Matsumoto et al
author_facet	Tetsuya Mutoh Masaya Nishio Yukihiro Matsumoto et al
author_sort	Tetsuya Mutoh
title	Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis
title_short	Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis
title_full	Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis
title_fullStr	Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis
title_full_unstemmed	Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis
title_sort	correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/c15b69f5b0bd467d89c7a4c013cd245d
work_keys_str_mv	AT tetsuyamutoh correlationbetweenthematrixmetalloproteinase9activityandchondroitinsulfateconcentrationsintearfluidafterlaserinsitukeratomileusis AT masayanishio correlationbetweenthematrixmetalloproteinase9activityandchondroitinsulfateconcentrationsintearfluidafterlaserinsitukeratomileusis AT yukihiromatsumoto correlationbetweenthematrixmetalloproteinase9activityandchondroitinsulfateconcentrationsintearfluidafterlaserinsitukeratomileusis AT etal correlationbetweenthematrixmetalloproteinase9activityandchondroitinsulfateconcentrationsintearfluidafterlaserinsitukeratomileusis
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Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis

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