Alzheimer’s Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet

Recently, type 2 diabetes mellitus (T2DM) has been reported to be strongly associated with Alzheimer’s disease (AD). This is partly due to insulin resistance in the brain. Insulin signaling and the number of insulin receptors may decline in the brain of T2DM patients, resulting in impaired synaptic...

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Autores principales:	Junpei Takeishi, Yasuko Tatewaki, Taizen Nakase, Yumi Takano, Naoki Tomita, Shuzo Yamamoto, Tatsushi Mutoh, Yasuyuki Taki
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease amyloid-beta type 2 diabetes mellitus insulin resistance glucose metabolism ketone metabolism Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c15bc720f16b47b6bf2c3a1a3469f368
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spelling	oai:doaj.org-article:c15bc720f16b47b6bf2c3a1a3469f3682021-11-25T17:55:18ZAlzheimer’s Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet10.3390/ijms2222123101422-00671661-6596https://doaj.org/article/c15bc720f16b47b6bf2c3a1a3469f3682021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12310https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Recently, type 2 diabetes mellitus (T2DM) has been reported to be strongly associated with Alzheimer’s disease (AD). This is partly due to insulin resistance in the brain. Insulin signaling and the number of insulin receptors may decline in the brain of T2DM patients, resulting in impaired synaptic formation, neuronal plasticity, and mitochondrial metabolism. In AD patients, hypometabolism of glucose in the brain is observed before the onset of symptoms. Amyloid-β accumulation, a main pathology of AD, also relates to impaired insulin action and glucose metabolism, although ketone metabolism is not affected. Therefore, the shift from glucose metabolism to ketone metabolism may be a reasonable pathway for neuronal protection. To promote ketone metabolism, medium-chain triglyceride (MCT) oil and a ketogenic diet could be introduced as an alternative source of energy in the brain of AD patients.Junpei TakeishiYasuko TatewakiTaizen NakaseYumi TakanoNaoki TomitaShuzo YamamotoTatsushi MutohYasuyuki TakiMDPI AGarticleAlzheimer’s diseaseamyloid-betatype 2 diabetes mellitusinsulin resistanceglucose metabolismketone metabolismBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12310, p 12310 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease amyloid-beta type 2 diabetes mellitus insulin resistance glucose metabolism ketone metabolism Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	Alzheimer’s disease amyloid-beta type 2 diabetes mellitus insulin resistance glucose metabolism ketone metabolism Biology (General) QH301-705.5 Chemistry QD1-999 Junpei Takeishi Yasuko Tatewaki Taizen Nakase Yumi Takano Naoki Tomita Shuzo Yamamoto Tatsushi Mutoh Yasuyuki Taki Alzheimer’s Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet
description	Recently, type 2 diabetes mellitus (T2DM) has been reported to be strongly associated with Alzheimer’s disease (AD). This is partly due to insulin resistance in the brain. Insulin signaling and the number of insulin receptors may decline in the brain of T2DM patients, resulting in impaired synaptic formation, neuronal plasticity, and mitochondrial metabolism. In AD patients, hypometabolism of glucose in the brain is observed before the onset of symptoms. Amyloid-β accumulation, a main pathology of AD, also relates to impaired insulin action and glucose metabolism, although ketone metabolism is not affected. Therefore, the shift from glucose metabolism to ketone metabolism may be a reasonable pathway for neuronal protection. To promote ketone metabolism, medium-chain triglyceride (MCT) oil and a ketogenic diet could be introduced as an alternative source of energy in the brain of AD patients.
format	article
author	Junpei Takeishi Yasuko Tatewaki Taizen Nakase Yumi Takano Naoki Tomita Shuzo Yamamoto Tatsushi Mutoh Yasuyuki Taki
author_facet	Junpei Takeishi Yasuko Tatewaki Taizen Nakase Yumi Takano Naoki Tomita Shuzo Yamamoto Tatsushi Mutoh Yasuyuki Taki
author_sort	Junpei Takeishi
title	Alzheimer’s Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet
title_short	Alzheimer’s Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet
title_full	Alzheimer’s Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet
title_fullStr	Alzheimer’s Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet
title_full_unstemmed	Alzheimer’s Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet
title_sort	alzheimer’s disease and type 2 diabetes mellitus: the use of mct oil and a ketogenic diet
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c15bc720f16b47b6bf2c3a1a3469f368
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Alzheimer’s Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet

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