Purslane (Portulaca oleracea) Ethanol Extract decreases hs-CRP levels and Total Score of Renal Tubular Degeneration in Rat Model of Gentamicine-Induced Renal Damage

Introduction: Injection of intraperitoneal gentamicin at a dose of 60 mg/kg BW intra-peritoneal in rats for 7 days has been shown to trigger renal tubular degeneration and increase in high sensitivity C-reactive protein (hs-CRP) level. The use of purslane (Portulaca oleracea) to reduce hs-CRP levels...

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Autores principales:	Ragil Saptaningtyas, Shofa Chasani, Taufiqurrachman Nasihun
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2021
Materias:	purslane ethanol extract, gentamicin, hs-crp levels, total score of renal tubular degeneration Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c15c57ef0a764b42bc4d1abb4ddf0bb3
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spelling	oai:doaj.org-article:c15c57ef0a764b42bc4d1abb4ddf0bb32021-11-25T13:16:44ZPurslane (Portulaca oleracea) Ethanol Extract decreases hs-CRP levels and Total Score of Renal Tubular Degeneration in Rat Model of Gentamicine-Induced Renal Damage2085-15452339-093X10.30659/sainsmed.v11i2.4092https://doaj.org/article/c15c57ef0a764b42bc4d1abb4ddf0bb32021-01-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/4092https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XIntroduction: Injection of intraperitoneal gentamicin at a dose of 60 mg/kg BW intra-peritoneal in rats for 7 days has been shown to trigger renal tubular degeneration and increase in high sensitivity C-reactive protein (hs-CRP) level. The use of purslane (Portulaca oleracea) to reduce hs-CRP levels and total score of renal tubular degeneration has not been reported. Objective: to determine the effect of purslane ethanol extract on hs-CRP levels and renal tubular degeneration score in gentamicin induced-renal damage in rats. Methods: This was a study using posttest only control group design. Twentyfive male Wistar rats aged 8-12 weeks, weighed 150-200 grams were allocated into 5 groups: normal (Nor-G), without treatment; negative (Neg-G), gentamicin (60 mg/kg BW), intraperitoneally; P-200; P-300 ; P-400 (gentamicin plus purslane extract at a dose of 200, 300, and 400 respectively) for 7 days. The hs-CRP was evaluated using the ELISA method. Total score of renal tubular degeneration was evaluated using modified score of Sarjadi. Results: there was a significant difference in mean hsCRP level and total score of renal tubular degeneration between groups (p <0.05). Posthoc analysis showed that hsCRP level and total score group of P-200, P-300 and P-400 were significantly lower than those of Neg-G, p <0.05. Meanwhile, the levels of hsCRP and total score of renal tubular degeneration in P-200, P-300, P-400, and Nor-G groups were not significantly different (p> 0.05). Conclusion: the administration of purslane ethanol extract at doses of 200, 300, and 400 mg/kg BW for 7 days improve hs-CRP level and total score of tubular degeneration similar to normal.Ragil SaptaningtyasShofa ChasaniTaufiqurrachman NasihunUniversitas Sultan Agung Semarangarticlepurslane ethanol extract, gentamicin, hs-crp levels, total score of renal tubular degenerationMedicine (General)R5-920ENSains Medika, Vol 11, Iss 2, Pp 74-80 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	purslane ethanol extract, gentamicin, hs-crp levels, total score of renal tubular degeneration Medicine (General) R5-920
spellingShingle	purslane ethanol extract, gentamicin, hs-crp levels, total score of renal tubular degeneration Medicine (General) R5-920 Ragil Saptaningtyas Shofa Chasani Taufiqurrachman Nasihun Purslane (Portulaca oleracea) Ethanol Extract decreases hs-CRP levels and Total Score of Renal Tubular Degeneration in Rat Model of Gentamicine-Induced Renal Damage
description	Introduction: Injection of intraperitoneal gentamicin at a dose of 60 mg/kg BW intra-peritoneal in rats for 7 days has been shown to trigger renal tubular degeneration and increase in high sensitivity C-reactive protein (hs-CRP) level. The use of purslane (Portulaca oleracea) to reduce hs-CRP levels and total score of renal tubular degeneration has not been reported. Objective: to determine the effect of purslane ethanol extract on hs-CRP levels and renal tubular degeneration score in gentamicin induced-renal damage in rats. Methods: This was a study using posttest only control group design. Twentyfive male Wistar rats aged 8-12 weeks, weighed 150-200 grams were allocated into 5 groups: normal (Nor-G), without treatment; negative (Neg-G), gentamicin (60 mg/kg BW), intraperitoneally; P-200; P-300 ; P-400 (gentamicin plus purslane extract at a dose of 200, 300, and 400 respectively) for 7 days. The hs-CRP was evaluated using the ELISA method. Total score of renal tubular degeneration was evaluated using modified score of Sarjadi. Results: there was a significant difference in mean hsCRP level and total score of renal tubular degeneration between groups (p <0.05). Posthoc analysis showed that hsCRP level and total score group of P-200, P-300 and P-400 were significantly lower than those of Neg-G, p <0.05. Meanwhile, the levels of hsCRP and total score of renal tubular degeneration in P-200, P-300, P-400, and Nor-G groups were not significantly different (p> 0.05). Conclusion: the administration of purslane ethanol extract at doses of 200, 300, and 400 mg/kg BW for 7 days improve hs-CRP level and total score of tubular degeneration similar to normal.
format	article
author	Ragil Saptaningtyas Shofa Chasani Taufiqurrachman Nasihun
author_facet	Ragil Saptaningtyas Shofa Chasani Taufiqurrachman Nasihun
author_sort	Ragil Saptaningtyas
title	Purslane (Portulaca oleracea) Ethanol Extract decreases hs-CRP levels and Total Score of Renal Tubular Degeneration in Rat Model of Gentamicine-Induced Renal Damage
title_short	Purslane (Portulaca oleracea) Ethanol Extract decreases hs-CRP levels and Total Score of Renal Tubular Degeneration in Rat Model of Gentamicine-Induced Renal Damage
title_full	Purslane (Portulaca oleracea) Ethanol Extract decreases hs-CRP levels and Total Score of Renal Tubular Degeneration in Rat Model of Gentamicine-Induced Renal Damage
title_fullStr	Purslane (Portulaca oleracea) Ethanol Extract decreases hs-CRP levels and Total Score of Renal Tubular Degeneration in Rat Model of Gentamicine-Induced Renal Damage
title_full_unstemmed	Purslane (Portulaca oleracea) Ethanol Extract decreases hs-CRP levels and Total Score of Renal Tubular Degeneration in Rat Model of Gentamicine-Induced Renal Damage
title_sort	purslane (portulaca oleracea) ethanol extract decreases hs-crp levels and total score of renal tubular degeneration in rat model of gentamicine-induced renal damage
publisher	Universitas Sultan Agung Semarang
publishDate	2021
url	https://doaj.org/article/c15c57ef0a764b42bc4d1abb4ddf0bb3
work_keys_str_mv	AT ragilsaptaningtyas purslaneportulacaoleraceaethanolextractdecreaseshscrplevelsandtotalscoreofrenaltubulardegenerationinratmodelofgentamicineinducedrenaldamage AT shofachasani purslaneportulacaoleraceaethanolextractdecreaseshscrplevelsandtotalscoreofrenaltubulardegenerationinratmodelofgentamicineinducedrenaldamage AT taufiqurrachmannasihun purslaneportulacaoleraceaethanolextractdecreaseshscrplevelsandtotalscoreofrenaltubulardegenerationinratmodelofgentamicineinducedrenaldamage
_version_	1718413524674281472

Purslane (Portulaca oleracea) Ethanol Extract decreases hs-CRP levels and Total Score of Renal Tubular Degeneration in Rat Model of Gentamicine-Induced Renal Damage

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