Degranulation enhances presynaptic membrane packing, which protects NK cells from perforin-mediated autolysis.
Natural killer (NK) cells kill a target cell by secreting perforin into the lytic immunological synapse, a specialized interface formed between the NK cell and its target. Perforin creates pores in target cell membranes allowing delivery of proapoptotic enzymes. Despite the fact that secreted perfor...
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| Auteurs principaux: | , |
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| Format: | article |
| Langue: | EN |
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Public Library of Science (PLoS)
2021
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| Accès en ligne: | https://doaj.org/article/c15feb9cd1be4103b9d07e6b8758bbb8 |
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