Essential hypertension: A filtered serum based metabolomics study

Abstract Despite the easy and reliable methods of blood pressure measurement, the screening of essential hypertension (EH) is usually ignored due to delayed onset of symptoms. A probe into the biochemical changes in hypertension would serve as a welcome asset to provide insight into the mechanistic...

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Autores principales:	Keerti Ameta, Ashish Gupta, Sudeep Kumar, Rishi Sethi, Deepak Kumar, Abbas Ali Mahdi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c1650d52f1474241827fe9bbd577ecd9
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spelling	oai:doaj.org-article:c1650d52f1474241827fe9bbd577ecd92021-12-02T12:30:25ZEssential hypertension: A filtered serum based metabolomics study10.1038/s41598-017-02289-92045-2322https://doaj.org/article/c1650d52f1474241827fe9bbd577ecd92017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02289-9https://doaj.org/toc/2045-2322Abstract Despite the easy and reliable methods of blood pressure measurement, the screening of essential hypertension (EH) is usually ignored due to delayed onset of symptoms. A probe into the biochemical changes in hypertension would serve as a welcome asset to provide insight into the mechanistic aspects of EH. Filtered serum samples from 64 EH patients and 59 healthy controls (HC) were analysed using 800 MHz nuclear magnetic resonance (NMR) spectroscopy. Application of principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) following receiver operating characteristic (ROC) curve of NMR data reveals significantly perturbed metabolites: alanine, arginine, methionine, pyruvate, adenine, and uracil. This set of metabolites correctly classified 99% of cases from HC and also showed excellent correlation in both isolated elevated diastolic blood pressure (DBP) cases and combined elevated systolic-diastolic blood pressure cases. Proton NMR metabolomics of EH may prove helpful in defining associated biomarkers and serve as an alternate diagnostic tool with judicious clinical assessment.Keerti AmetaAshish GuptaSudeep KumarRishi SethiDeepak KumarAbbas Ali MahdiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Keerti Ameta Ashish Gupta Sudeep Kumar Rishi Sethi Deepak Kumar Abbas Ali Mahdi Essential hypertension: A filtered serum based metabolomics study
description	Abstract Despite the easy and reliable methods of blood pressure measurement, the screening of essential hypertension (EH) is usually ignored due to delayed onset of symptoms. A probe into the biochemical changes in hypertension would serve as a welcome asset to provide insight into the mechanistic aspects of EH. Filtered serum samples from 64 EH patients and 59 healthy controls (HC) were analysed using 800 MHz nuclear magnetic resonance (NMR) spectroscopy. Application of principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) following receiver operating characteristic (ROC) curve of NMR data reveals significantly perturbed metabolites: alanine, arginine, methionine, pyruvate, adenine, and uracil. This set of metabolites correctly classified 99% of cases from HC and also showed excellent correlation in both isolated elevated diastolic blood pressure (DBP) cases and combined elevated systolic-diastolic blood pressure cases. Proton NMR metabolomics of EH may prove helpful in defining associated biomarkers and serve as an alternate diagnostic tool with judicious clinical assessment.
format	article
author	Keerti Ameta Ashish Gupta Sudeep Kumar Rishi Sethi Deepak Kumar Abbas Ali Mahdi
author_facet	Keerti Ameta Ashish Gupta Sudeep Kumar Rishi Sethi Deepak Kumar Abbas Ali Mahdi
author_sort	Keerti Ameta
title	Essential hypertension: A filtered serum based metabolomics study
title_short	Essential hypertension: A filtered serum based metabolomics study
title_full	Essential hypertension: A filtered serum based metabolomics study
title_fullStr	Essential hypertension: A filtered serum based metabolomics study
title_full_unstemmed	Essential hypertension: A filtered serum based metabolomics study
title_sort	essential hypertension: a filtered serum based metabolomics study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c1650d52f1474241827fe9bbd577ecd9
work_keys_str_mv	AT keertiameta essentialhypertensionafilteredserumbasedmetabolomicsstudy AT ashishgupta essentialhypertensionafilteredserumbasedmetabolomicsstudy AT sudeepkumar essentialhypertensionafilteredserumbasedmetabolomicsstudy AT rishisethi essentialhypertensionafilteredserumbasedmetabolomicsstudy AT deepakkumar essentialhypertensionafilteredserumbasedmetabolomicsstudy AT abbasalimahdi essentialhypertensionafilteredserumbasedmetabolomicsstudy
_version_	1718394421853028352

Essential hypertension: A filtered serum based metabolomics study

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