Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity

Abstract Prognostic markers are needed to understand the disease course and severity in patients with Covid-19. There is evidence that Covid-19 causes gastrointestinal symptoms and abnormalities in liver enzymes. We aimed to determine if hepatobiliary laboratory data could predict disease severity i...

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Autores principales:	Jason Wagner, Victor Garcia-Rodriguez, Abraham Yu, Barbara Dutra, Scott Larson, Brooks Cash, Andrew DuPont, Ahmad Farooq
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c16739b7d0d04709b1fa1ea2a1c8ef54
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spelling	oai:doaj.org-article:c16739b7d0d04709b1fa1ea2a1c8ef542021-12-02T17:15:36ZElevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity10.1038/s41598-021-89340-y2045-2322https://doaj.org/article/c16739b7d0d04709b1fa1ea2a1c8ef542021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89340-yhttps://doaj.org/toc/2045-2322Abstract Prognostic markers are needed to understand the disease course and severity in patients with Covid-19. There is evidence that Covid-19 causes gastrointestinal symptoms and abnormalities in liver enzymes. We aimed to determine if hepatobiliary laboratory data could predict disease severity in patients with Covid-19. In this retrospective, single institution, cohort study that analyzed patients admitted to a community academic hospital with the diagnosis of Covid-19, we found that elevations of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline Phosphatase (AP) at any time during hospital admission increased the odds of ICU admission by 5.12 (95% CI: 1.55–16.89; p = 0.007), 4.71 (95% CI: 1.51–14.69; p = 0.01) and 4.12 (95% CI: 1.21–14.06, p = 0.02), respectively. Hypoalbuminemia found at the time of admission to the hospital was associated with increased mortality (p = 0.02), hypotension (p = 0.03), and need for vasopressors (p = 0.02), intubation (p = 0.01) and hemodialysis (p = 0.002). Additionally, there was evidence of liver injury: AST was significantly elevated above baseline in patients admitted to the ICU (54.2 ± 15.70 U/L) relative to those who were not (9.2 ± 4.89 U/L; p = 0.01). Taken together, this study found that hypoalbuminemia and abnormalities in hepatobiliary laboratory data may be prognostic factors for disease severity in patients admitted to the hospital with Covid-19.Jason WagnerVictor Garcia-RodriguezAbraham YuBarbara DutraScott LarsonBrooks CashAndrew DuPontAhmad FarooqNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jason Wagner Victor Garcia-Rodriguez Abraham Yu Barbara Dutra Scott Larson Brooks Cash Andrew DuPont Ahmad Farooq Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity
description	Abstract Prognostic markers are needed to understand the disease course and severity in patients with Covid-19. There is evidence that Covid-19 causes gastrointestinal symptoms and abnormalities in liver enzymes. We aimed to determine if hepatobiliary laboratory data could predict disease severity in patients with Covid-19. In this retrospective, single institution, cohort study that analyzed patients admitted to a community academic hospital with the diagnosis of Covid-19, we found that elevations of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline Phosphatase (AP) at any time during hospital admission increased the odds of ICU admission by 5.12 (95% CI: 1.55–16.89; p = 0.007), 4.71 (95% CI: 1.51–14.69; p = 0.01) and 4.12 (95% CI: 1.21–14.06, p = 0.02), respectively. Hypoalbuminemia found at the time of admission to the hospital was associated with increased mortality (p = 0.02), hypotension (p = 0.03), and need for vasopressors (p = 0.02), intubation (p = 0.01) and hemodialysis (p = 0.002). Additionally, there was evidence of liver injury: AST was significantly elevated above baseline in patients admitted to the ICU (54.2 ± 15.70 U/L) relative to those who were not (9.2 ± 4.89 U/L; p = 0.01). Taken together, this study found that hypoalbuminemia and abnormalities in hepatobiliary laboratory data may be prognostic factors for disease severity in patients admitted to the hospital with Covid-19.
format	article
author	Jason Wagner Victor Garcia-Rodriguez Abraham Yu Barbara Dutra Scott Larson Brooks Cash Andrew DuPont Ahmad Farooq
author_facet	Jason Wagner Victor Garcia-Rodriguez Abraham Yu Barbara Dutra Scott Larson Brooks Cash Andrew DuPont Ahmad Farooq
author_sort	Jason Wagner
title	Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity
title_short	Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity
title_full	Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity
title_fullStr	Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity
title_full_unstemmed	Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity
title_sort	elevated transaminases and hypoalbuminemia in covid-19 are prognostic factors for disease severity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c16739b7d0d04709b1fa1ea2a1c8ef54
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Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity

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