Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity

Abstract Prognostic markers are needed to understand the disease course and severity in patients with Covid-19. There is evidence that Covid-19 causes gastrointestinal symptoms and abnormalities in liver enzymes. We aimed to determine if hepatobiliary laboratory data could predict disease severity i...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jason Wagner, Victor Garcia-Rodriguez, Abraham Yu, Barbara Dutra, Scott Larson, Brooks Cash, Andrew DuPont, Ahmad Farooq
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/c16739b7d0d04709b1fa1ea2a1c8ef54
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:c16739b7d0d04709b1fa1ea2a1c8ef54
record_format dspace
spelling oai:doaj.org-article:c16739b7d0d04709b1fa1ea2a1c8ef542021-12-02T17:15:36ZElevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity10.1038/s41598-021-89340-y2045-2322https://doaj.org/article/c16739b7d0d04709b1fa1ea2a1c8ef542021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89340-yhttps://doaj.org/toc/2045-2322Abstract Prognostic markers are needed to understand the disease course and severity in patients with Covid-19. There is evidence that Covid-19 causes gastrointestinal symptoms and abnormalities in liver enzymes. We aimed to determine if hepatobiliary laboratory data could predict disease severity in patients with Covid-19. In this retrospective, single institution, cohort study that analyzed patients admitted to a community academic hospital with the diagnosis of Covid-19, we found that elevations of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline Phosphatase (AP) at any time during hospital admission increased the odds of ICU admission by 5.12 (95% CI: 1.55–16.89; p = 0.007), 4.71 (95% CI: 1.51–14.69; p = 0.01) and 4.12 (95% CI: 1.21–14.06, p = 0.02), respectively. Hypoalbuminemia found at the time of admission to the hospital was associated with increased mortality (p = 0.02), hypotension (p = 0.03), and need for vasopressors (p = 0.02), intubation (p = 0.01) and hemodialysis (p = 0.002). Additionally, there was evidence of liver injury: AST was significantly elevated above baseline in patients admitted to the ICU (54.2 ± 15.70 U/L) relative to those who were not (9.2 ± 4.89 U/L; p = 0.01). Taken together, this study found that hypoalbuminemia and abnormalities in hepatobiliary laboratory data may be prognostic factors for disease severity in patients admitted to the hospital with Covid-19.Jason WagnerVictor Garcia-RodriguezAbraham YuBarbara DutraScott LarsonBrooks CashAndrew DuPontAhmad FarooqNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Jason Wagner
Victor Garcia-Rodriguez
Abraham Yu
Barbara Dutra
Scott Larson
Brooks Cash
Andrew DuPont
Ahmad Farooq
Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity
description Abstract Prognostic markers are needed to understand the disease course and severity in patients with Covid-19. There is evidence that Covid-19 causes gastrointestinal symptoms and abnormalities in liver enzymes. We aimed to determine if hepatobiliary laboratory data could predict disease severity in patients with Covid-19. In this retrospective, single institution, cohort study that analyzed patients admitted to a community academic hospital with the diagnosis of Covid-19, we found that elevations of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline Phosphatase (AP) at any time during hospital admission increased the odds of ICU admission by 5.12 (95% CI: 1.55–16.89; p = 0.007), 4.71 (95% CI: 1.51–14.69; p = 0.01) and 4.12 (95% CI: 1.21–14.06, p = 0.02), respectively. Hypoalbuminemia found at the time of admission to the hospital was associated with increased mortality (p = 0.02), hypotension (p = 0.03), and need for vasopressors (p = 0.02), intubation (p = 0.01) and hemodialysis (p = 0.002). Additionally, there was evidence of liver injury: AST was significantly elevated above baseline in patients admitted to the ICU (54.2 ± 15.70 U/L) relative to those who were not (9.2 ± 4.89 U/L; p = 0.01). Taken together, this study found that hypoalbuminemia and abnormalities in hepatobiliary laboratory data may be prognostic factors for disease severity in patients admitted to the hospital with Covid-19.
format article
author Jason Wagner
Victor Garcia-Rodriguez
Abraham Yu
Barbara Dutra
Scott Larson
Brooks Cash
Andrew DuPont
Ahmad Farooq
author_facet Jason Wagner
Victor Garcia-Rodriguez
Abraham Yu
Barbara Dutra
Scott Larson
Brooks Cash
Andrew DuPont
Ahmad Farooq
author_sort Jason Wagner
title Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity
title_short Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity
title_full Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity
title_fullStr Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity
title_full_unstemmed Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity
title_sort elevated transaminases and hypoalbuminemia in covid-19 are prognostic factors for disease severity
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c16739b7d0d04709b1fa1ea2a1c8ef54
work_keys_str_mv AT jasonwagner elevatedtransaminasesandhypoalbuminemiaincovid19areprognosticfactorsfordiseaseseverity
AT victorgarciarodriguez elevatedtransaminasesandhypoalbuminemiaincovid19areprognosticfactorsfordiseaseseverity
AT abrahamyu elevatedtransaminasesandhypoalbuminemiaincovid19areprognosticfactorsfordiseaseseverity
AT barbaradutra elevatedtransaminasesandhypoalbuminemiaincovid19areprognosticfactorsfordiseaseseverity
AT scottlarson elevatedtransaminasesandhypoalbuminemiaincovid19areprognosticfactorsfordiseaseseverity
AT brookscash elevatedtransaminasesandhypoalbuminemiaincovid19areprognosticfactorsfordiseaseseverity
AT andrewdupont elevatedtransaminasesandhypoalbuminemiaincovid19areprognosticfactorsfordiseaseseverity
AT ahmadfarooq elevatedtransaminasesandhypoalbuminemiaincovid19areprognosticfactorsfordiseaseseverity
_version_ 1718381283914022912