In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

T cells from narcolepsy patients were recently reported to recognize hypocretin, a wakefulness-promoting neurohormone, suggesting autoimmune origin of the disease. Here the authors show that hypocretin-specific T cells expand both in healthy controls and in narcolepsy patients, and identify prelimin...

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Autores principales:	Wei Jiang, James R. Birtley, Shu-Chen Hung, Weiqi Wang, Shin-Heng Chiou, Claudia Macaubas, Birgitte Kornum, Lu Tian, Huang Huang, Lital Adler, Grant Weaver, Liying Lu, Alexandra Ilstad-Minnihan, Sriram Somasundaram, Sashi Ayyangar, Mark M. Davis, Lawrence J. Stern, Elizabeth D. Mellins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c167c2cc9a574287872bf608f7e73845
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spelling	oai:doaj.org-article:c167c2cc9a574287872bf608f7e738452021-12-02T16:57:21ZIn vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls10.1038/s41467-019-13234-x2041-1723https://doaj.org/article/c167c2cc9a574287872bf608f7e738452019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13234-xhttps://doaj.org/toc/2041-1723T cells from narcolepsy patients were recently reported to recognize hypocretin, a wakefulness-promoting neurohormone, suggesting autoimmune origin of the disease. Here the authors show that hypocretin-specific T cells expand both in healthy controls and in narcolepsy patients, and identify preliminary features that may distinguish them.Wei JiangJames R. BirtleyShu-Chen HungWeiqi WangShin-Heng ChiouClaudia MacaubasBirgitte KornumLu TianHuang HuangLital AdlerGrant WeaverLiying LuAlexandra Ilstad-MinnihanSriram SomasundaramSashi AyyangarMark M. DavisLawrence J. SternElizabeth D. MellinsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Jiang James R. Birtley Shu-Chen Hung Weiqi Wang Shin-Heng Chiou Claudia Macaubas Birgitte Kornum Lu Tian Huang Huang Lital Adler Grant Weaver Liying Lu Alexandra Ilstad-Minnihan Sriram Somasundaram Sashi Ayyangar Mark M. Davis Lawrence J. Stern Elizabeth D. Mellins In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
description	T cells from narcolepsy patients were recently reported to recognize hypocretin, a wakefulness-promoting neurohormone, suggesting autoimmune origin of the disease. Here the authors show that hypocretin-specific T cells expand both in healthy controls and in narcolepsy patients, and identify preliminary features that may distinguish them.
format	article
author	Wei Jiang James R. Birtley Shu-Chen Hung Weiqi Wang Shin-Heng Chiou Claudia Macaubas Birgitte Kornum Lu Tian Huang Huang Lital Adler Grant Weaver Liying Lu Alexandra Ilstad-Minnihan Sriram Somasundaram Sashi Ayyangar Mark M. Davis Lawrence J. Stern Elizabeth D. Mellins
author_facet	Wei Jiang James R. Birtley Shu-Chen Hung Weiqi Wang Shin-Heng Chiou Claudia Macaubas Birgitte Kornum Lu Tian Huang Huang Lital Adler Grant Weaver Liying Lu Alexandra Ilstad-Minnihan Sriram Somasundaram Sashi Ayyangar Mark M. Davis Lawrence J. Stern Elizabeth D. Mellins
author_sort	Wei Jiang
title	In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
title_short	In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
title_full	In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
title_fullStr	In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
title_full_unstemmed	In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
title_sort	in vivo clonal expansion and phenotypes of hypocretin-specific cd4+ t cells in narcolepsy patients and controls
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c167c2cc9a574287872bf608f7e73845
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In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

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