Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance

In breast cancer, the 3D architecture of the genome can impact gene regulation. Here, the authors use tethered chromatin conformation profiling to investigate 3D chromatin structure in models of hormone-induced breast cancer and endocrine resistance, finding dynamic temporal reorganisation.

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Autores principales:	Yufan Zhou, Diana L. Gerrard, Junbai Wang, Tian Li, Yini Yang, Andrew J. Fritz, Mahitha Rajendran, Xiaoyong Fu, Gary Stein, Rachel Schiff, Shili Lin, Seth Frietze, Victor X. Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c168bfd68f6544dfa59367262175a08f
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spelling	oai:doaj.org-article:c168bfd68f6544dfa59367262175a08f2021-12-02T15:35:39ZTemporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance10.1038/s41467-019-09320-92041-1723https://doaj.org/article/c168bfd68f6544dfa59367262175a08f2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09320-9https://doaj.org/toc/2041-1723In breast cancer, the 3D architecture of the genome can impact gene regulation. Here, the authors use tethered chromatin conformation profiling to investigate 3D chromatin structure in models of hormone-induced breast cancer and endocrine resistance, finding dynamic temporal reorganisation.Yufan ZhouDiana L. GerrardJunbai WangTian LiYini YangAndrew J. FritzMahitha RajendranXiaoyong FuGary SteinRachel SchiffShili LinSeth FrietzeVictor X. JinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yufan Zhou Diana L. Gerrard Junbai Wang Tian Li Yini Yang Andrew J. Fritz Mahitha Rajendran Xiaoyong Fu Gary Stein Rachel Schiff Shili Lin Seth Frietze Victor X. Jin Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance
description	In breast cancer, the 3D architecture of the genome can impact gene regulation. Here, the authors use tethered chromatin conformation profiling to investigate 3D chromatin structure in models of hormone-induced breast cancer and endocrine resistance, finding dynamic temporal reorganisation.
format	article
author	Yufan Zhou Diana L. Gerrard Junbai Wang Tian Li Yini Yang Andrew J. Fritz Mahitha Rajendran Xiaoyong Fu Gary Stein Rachel Schiff Shili Lin Seth Frietze Victor X. Jin
author_facet	Yufan Zhou Diana L. Gerrard Junbai Wang Tian Li Yini Yang Andrew J. Fritz Mahitha Rajendran Xiaoyong Fu Gary Stein Rachel Schiff Shili Lin Seth Frietze Victor X. Jin
author_sort	Yufan Zhou
title	Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance
title_short	Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance
title_full	Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance
title_fullStr	Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance
title_full_unstemmed	Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance
title_sort	temporal dynamic reorganization of 3d chromatin architecture in hormone-induced breast cancer and endocrine resistance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c168bfd68f6544dfa59367262175a08f
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Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance

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