Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour

Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour

The suprachiasmatic nucleus (SCN) is the central regulator of circadian rhythms. Here the authors identify mouse Gpr176 as a pace modulator of this circadian clock and characterize its mode of action as coupling to Gz rather than Gi subunits.

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Bibliographic Details
Main Authors: Masao Doi, Iori Murai, Sumihiro Kunisue, Genzui Setsu, Naohiro Uchio, Rina Tanaka, Sakurako Kobayashi, Hiroyuki Shimatani, Hida Hayashi, Hsu-Wen Chao, Yuuki Nakagawa, Yukari Takahashi, Yunhong Hotta, Jun-ichirou Yasunaga, Masao Matsuoka, Michael H. Hastings, Hiroshi Kiyonari, Hitoshi Okamura
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/c16b11b6441e475eb897bd5b32fd2eac
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