Structural basis of inhibition of a transporter from Staphylococcus aureus, NorC, through a single-domain camelid antibody
Sushant Kumar et. al. report the 3.6 Å resolution crystal structure of NorC, a 14-transmembrane major facilitator superfamily member that is implicated in fluoroquinolone resistance in drug-resistant Staphylococcus aureus strains. The NorC structure was determined in complex with a single-domain cam...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c16c7af762f549619faaeddc0375f262 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | Sushant Kumar et. al. report the 3.6 Å resolution crystal structure of NorC, a 14-transmembrane major facilitator superfamily member that is implicated in fluoroquinolone resistance in drug-resistant Staphylococcus aureus strains. The NorC structure was determined in complex with a single-domain camelid antibody that blocks access to the transporter and thus constitutes a new mode of inhibition. |
|---|