K63-linked ubiquitylation induces global sequestration of mitochondria

K63-linked ubiquitylation induces global sequestration of mitochondria

Abstract Even though K63-linked polyubiquitin chains do not target proteins for proteasomal degradation, they play nevertheless a complementary protective role in maintaining protein homeostasis by directing malfunctioning proteins and organelles to inclusion bodies or autophagosomes. A paradigm for...

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Autores principales: Thibaud J. C. Richard, Laura K. Herzog, Julia Vornberger, Aldwin Suryo Rahmanto, Olle Sangfelt, Florian A. Salomons, Nico P. Dantuma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/c16e088089de40dbade83e4e69e958b1
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