Potential role of intravitreal human placental stem cell implants in inhibiting progression of diabetic retinopathy in type 2 diabetes: neuroprotective growth factors in the vitreous

Sergio Zaccaria Scalinci1,2, Lucia Scorolli1,2, Giulia Corradetti1,2, Daniela Domanico4, Enzo Maria Vingolo4, Alessandro Meduri5, Mario Bifani6, Duilio Siravo71Glaucoma and Low Vision Study Center, Department of General Surgery and Organ Transplants, University of Bologna, Bologna; 2Departments of O...

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Autores principales:	Scalinci SZ, Scorolli L, Corradetti G, Domanico D, Vingolo EM, Meduri A, Bifani M, Siravo D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c171b8bf82df452ebc1effa795d8deef
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spelling	oai:doaj.org-article:c171b8bf82df452ebc1effa795d8deef2021-12-02T05:31:11ZPotential role of intravitreal human placental stem cell implants in inhibiting progression of diabetic retinopathy in type 2 diabetes: neuroprotective growth factors in the vitreous1177-54671177-5483https://doaj.org/article/c171b8bf82df452ebc1effa795d8deef2011-05-01T00:00:00Zhttp://www.dovepress.com/potential-role-of-intravitreal-human-placental-stem-cell-implants-in-i-a7508https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Sergio Zaccaria Scalinci1,2, Lucia Scorolli1,2, Giulia Corradetti1,2, Daniela Domanico4, Enzo Maria Vingolo4, Alessandro Meduri5, Mario Bifani6, Duilio Siravo71Glaucoma and Low Vision Study Center, Department of General Surgery and Organ Transplants, University of Bologna, Bologna; 2Departments of Ophthalmology, S Orsola, Malpighi Hospital, Bologna; 3SM Goretti Hospital, Latina; 4University of Rome &quot;La Sapienza&quot;, Rome; 5University of Messina, Messina; 6Second University of Naples, Naples; 7US Army Health Clinic, Camp Darby of Livorno, Livorno, ItalyBackground: Intravitreal injection of human mesenchymal stem cells has been shown to be effective in slowing the progression of diabetic retinopathy in an animal model of chemically induced diabetes mellitus. We studied changes in growth factor levels released from human mesenchymal stem cells in the vitreous cavity as well as changes in growth factor levels in host retinal neurons following intravitreal injection.Methods: Twenty-two Lewis rats were treated with an intravitreal human mesenchymal stem cell microinjection. Determination of neurotrophic factors released by human mesenchymal stem cells in the vitreous was carried out using real-time polymerase chain reaction.Results: Detectable levels of neurotrophic factors were identified postoperatively in the vitreous of all rats.Conclusion: Increased intravitreal and retinal concentrations of neuroprotective growth factors in rats confirm the neuroprotective activity of human mesenchymal stem cells in diabetic retinopathy.Keywords: diabetic retinopathy, neuroprotection, apoptosis mechanism, stem cells, chemically induced diabetes mellitusScalinci SZScorolli LCorradetti GDomanico DVingolo EMMeduri ABifani MSiravo DDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 691-696 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Scalinci SZ Scorolli L Corradetti G Domanico D Vingolo EM Meduri A Bifani M Siravo D Potential role of intravitreal human placental stem cell implants in inhibiting progression of diabetic retinopathy in type 2 diabetes: neuroprotective growth factors in the vitreous
description	Sergio Zaccaria Scalinci1,2, Lucia Scorolli1,2, Giulia Corradetti1,2, Daniela Domanico4, Enzo Maria Vingolo4, Alessandro Meduri5, Mario Bifani6, Duilio Siravo71Glaucoma and Low Vision Study Center, Department of General Surgery and Organ Transplants, University of Bologna, Bologna; 2Departments of Ophthalmology, S Orsola, Malpighi Hospital, Bologna; 3SM Goretti Hospital, Latina; 4University of Rome &quot;La Sapienza&quot;, Rome; 5University of Messina, Messina; 6Second University of Naples, Naples; 7US Army Health Clinic, Camp Darby of Livorno, Livorno, ItalyBackground: Intravitreal injection of human mesenchymal stem cells has been shown to be effective in slowing the progression of diabetic retinopathy in an animal model of chemically induced diabetes mellitus. We studied changes in growth factor levels released from human mesenchymal stem cells in the vitreous cavity as well as changes in growth factor levels in host retinal neurons following intravitreal injection.Methods: Twenty-two Lewis rats were treated with an intravitreal human mesenchymal stem cell microinjection. Determination of neurotrophic factors released by human mesenchymal stem cells in the vitreous was carried out using real-time polymerase chain reaction.Results: Detectable levels of neurotrophic factors were identified postoperatively in the vitreous of all rats.Conclusion: Increased intravitreal and retinal concentrations of neuroprotective growth factors in rats confirm the neuroprotective activity of human mesenchymal stem cells in diabetic retinopathy.Keywords: diabetic retinopathy, neuroprotection, apoptosis mechanism, stem cells, chemically induced diabetes mellitus
format	article
author	Scalinci SZ Scorolli L Corradetti G Domanico D Vingolo EM Meduri A Bifani M Siravo D
author_facet	Scalinci SZ Scorolli L Corradetti G Domanico D Vingolo EM Meduri A Bifani M Siravo D
author_sort	Scalinci SZ
title	Potential role of intravitreal human placental stem cell implants in inhibiting progression of diabetic retinopathy in type 2 diabetes: neuroprotective growth factors in the vitreous
title_short	Potential role of intravitreal human placental stem cell implants in inhibiting progression of diabetic retinopathy in type 2 diabetes: neuroprotective growth factors in the vitreous
title_full	Potential role of intravitreal human placental stem cell implants in inhibiting progression of diabetic retinopathy in type 2 diabetes: neuroprotective growth factors in the vitreous
title_fullStr	Potential role of intravitreal human placental stem cell implants in inhibiting progression of diabetic retinopathy in type 2 diabetes: neuroprotective growth factors in the vitreous
title_full_unstemmed	Potential role of intravitreal human placental stem cell implants in inhibiting progression of diabetic retinopathy in type 2 diabetes: neuroprotective growth factors in the vitreous
title_sort	potential role of intravitreal human placental stem cell implants in inhibiting progression of diabetic retinopathy in type 2 diabetes: neuroprotective growth factors in the vitreous
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/c171b8bf82df452ebc1effa795d8deef
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Potential role of intravitreal human placental stem cell implants in inhibiting progression of diabetic retinopathy in type 2 diabetes: neuroprotective growth factors in the vitreous

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