Structural basis of complement membrane attack complex formation

The membrane attack complex (MAC) is an immune effector that kills pathogens by forming pores in their membrane. Here the authors use cryo-electron microscopy to reveal that the full MAC is an asymmetric pore with a split-washer configuration and identify a network of interactions that provide a bas...

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Autores principales:	Marina Serna, Joanna L. Giles, B. Paul Morgan, Doryen Bubeck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1758f53fff24aeaa7aaf0764e26cd76
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spelling	oai:doaj.org-article:c1758f53fff24aeaa7aaf0764e26cd762021-12-02T16:58:23ZStructural basis of complement membrane attack complex formation10.1038/ncomms105872041-1723https://doaj.org/article/c1758f53fff24aeaa7aaf0764e26cd762016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10587https://doaj.org/toc/2041-1723The membrane attack complex (MAC) is an immune effector that kills pathogens by forming pores in their membrane. Here the authors use cryo-electron microscopy to reveal that the full MAC is an asymmetric pore with a split-washer configuration and identify a network of interactions that provide a basis for sequential assembly.Marina SernaJoanna L. GilesB. Paul MorganDoryen BubeckNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marina Serna Joanna L. Giles B. Paul Morgan Doryen Bubeck Structural basis of complement membrane attack complex formation
description	The membrane attack complex (MAC) is an immune effector that kills pathogens by forming pores in their membrane. Here the authors use cryo-electron microscopy to reveal that the full MAC is an asymmetric pore with a split-washer configuration and identify a network of interactions that provide a basis for sequential assembly.
format	article
author	Marina Serna Joanna L. Giles B. Paul Morgan Doryen Bubeck
author_facet	Marina Serna Joanna L. Giles B. Paul Morgan Doryen Bubeck
author_sort	Marina Serna
title	Structural basis of complement membrane attack complex formation
title_short	Structural basis of complement membrane attack complex formation
title_full	Structural basis of complement membrane attack complex formation
title_fullStr	Structural basis of complement membrane attack complex formation
title_full_unstemmed	Structural basis of complement membrane attack complex formation
title_sort	structural basis of complement membrane attack complex formation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c1758f53fff24aeaa7aaf0764e26cd76
work_keys_str_mv	AT marinaserna structuralbasisofcomplementmembraneattackcomplexformation AT joannalgiles structuralbasisofcomplementmembraneattackcomplexformation AT bpaulmorgan structuralbasisofcomplementmembraneattackcomplexformation AT doryenbubeck structuralbasisofcomplementmembraneattackcomplexformation
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Structural basis of complement membrane attack complex formation

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