Structural basis of complement membrane attack complex formation

The membrane attack complex (MAC) is an immune effector that kills pathogens by forming pores in their membrane. Here the authors use cryo-electron microscopy to reveal that the full MAC is an asymmetric pore with a split-washer configuration and identify a network of interactions that provide a bas...

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Autores principales: Marina Serna, Joanna L. Giles, B. Paul Morgan, Doryen Bubeck
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/c1758f53fff24aeaa7aaf0764e26cd76
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