Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients
Abstract Postoperative acute exacerbation of interstitial lung disease (AE-ILD) can be fatal in patients with lung cancer concomitant with ILD. We aimed to elucidate the predictive potential of high-mobility group box 1 (HMGB1), which is associated with the development and severity of lung injury, f...
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Nature Portfolio
2021
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oai:doaj.org-article:c1783920c77d409799bc679315126ce62021-12-02T16:50:37ZPredictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients10.1038/s41598-021-89663-w2045-2322https://doaj.org/article/c1783920c77d409799bc679315126ce62021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89663-whttps://doaj.org/toc/2045-2322Abstract Postoperative acute exacerbation of interstitial lung disease (AE-ILD) can be fatal in patients with lung cancer concomitant with ILD. We aimed to elucidate the predictive potential of high-mobility group box 1 (HMGB1), which is associated with the development and severity of lung injury, for evaluating the risk of this complication. We included 152 patients with lung cancer and ILD who underwent radical surgery between January 2011 and August 2019. We evaluated the preoperative levels of serum HMGB1 and its predictive potential for postoperative AE-ILD. Postoperative AE-ILD developed in 17 patients. Serum levels of HMGB1 were significantly higher in patients with postoperative AE-ILD than in those without (median [interquartile range]: 5.39 [3.29–11.70] ng/mL vs. 3.55 [2.07–5.62] ng/mL). Univariate and multivariate logistic regression analyses revealed that higher HMGB1 levels were significantly associated with the development of postoperative AE-ILD in entire studied patients (n = 152). In the subgroup analysis, higher HMGB1 levels were associated with a significantly increased risk of this complication in patients who underwent lobectomy (n = 77) than in those who underwent sublobar resection (n = 75). Serum HMGB1 could be a promising marker for evaluating the risk of postoperative AE-ILD, specifically in patients who underwent lobectomy.Kakuhiro YamaguchiSatoshi NakaoHiroshi IwamotoAtsushi KagimotoYoshinori HandaShinjiro SakamotoYasushi HorimasuTakeshi MasudaTakahiro MimaeShintaro MiyamotoTaku NakashimaYasuhiro TsutaniKazunori FujitakaYoshihiro MiyataHironobu HamadaMorihito OkadaNoboru HattoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Kakuhiro Yamaguchi Satoshi Nakao Hiroshi Iwamoto Atsushi Kagimoto Yoshinori Handa Shinjiro Sakamoto Yasushi Horimasu Takeshi Masuda Takahiro Mimae Shintaro Miyamoto Taku Nakashima Yasuhiro Tsutani Kazunori Fujitaka Yoshihiro Miyata Hironobu Hamada Morihito Okada Noboru Hattori Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients |
| description |
Abstract Postoperative acute exacerbation of interstitial lung disease (AE-ILD) can be fatal in patients with lung cancer concomitant with ILD. We aimed to elucidate the predictive potential of high-mobility group box 1 (HMGB1), which is associated with the development and severity of lung injury, for evaluating the risk of this complication. We included 152 patients with lung cancer and ILD who underwent radical surgery between January 2011 and August 2019. We evaluated the preoperative levels of serum HMGB1 and its predictive potential for postoperative AE-ILD. Postoperative AE-ILD developed in 17 patients. Serum levels of HMGB1 were significantly higher in patients with postoperative AE-ILD than in those without (median [interquartile range]: 5.39 [3.29–11.70] ng/mL vs. 3.55 [2.07–5.62] ng/mL). Univariate and multivariate logistic regression analyses revealed that higher HMGB1 levels were significantly associated with the development of postoperative AE-ILD in entire studied patients (n = 152). In the subgroup analysis, higher HMGB1 levels were associated with a significantly increased risk of this complication in patients who underwent lobectomy (n = 77) than in those who underwent sublobar resection (n = 75). Serum HMGB1 could be a promising marker for evaluating the risk of postoperative AE-ILD, specifically in patients who underwent lobectomy. |
| format |
article |
| author |
Kakuhiro Yamaguchi Satoshi Nakao Hiroshi Iwamoto Atsushi Kagimoto Yoshinori Handa Shinjiro Sakamoto Yasushi Horimasu Takeshi Masuda Takahiro Mimae Shintaro Miyamoto Taku Nakashima Yasuhiro Tsutani Kazunori Fujitaka Yoshihiro Miyata Hironobu Hamada Morihito Okada Noboru Hattori |
| author_facet |
Kakuhiro Yamaguchi Satoshi Nakao Hiroshi Iwamoto Atsushi Kagimoto Yoshinori Handa Shinjiro Sakamoto Yasushi Horimasu Takeshi Masuda Takahiro Mimae Shintaro Miyamoto Taku Nakashima Yasuhiro Tsutani Kazunori Fujitaka Yoshihiro Miyata Hironobu Hamada Morihito Okada Noboru Hattori |
| author_sort |
Kakuhiro Yamaguchi |
| title |
Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients |
| title_short |
Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients |
| title_full |
Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients |
| title_fullStr |
Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients |
| title_full_unstemmed |
Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients |
| title_sort |
predictive role of circulatory hmgb1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c1783920c77d409799bc679315126ce6 |
| work_keys_str_mv |
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1718383063856054272 |