Biofilm modifies expression of ribonucleotide reductase genes in Escherichia coli.

Ribonucleotide reductase (RNR) is an essential enzyme for all living organisms since is the responsible for the last step in the synthesis of the four deoxyribonucleotides (dNTPs) necessary for DNA replication and repair. In this work, we have investigated the expression of the three-RNR classes (Ia...

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Autores principales:	Maria del Mar Cendra, Antonio Juárez, Eduard Torrents
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c17ec9e3a89d41ad9ab485919d24af16
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spelling	oai:doaj.org-article:c17ec9e3a89d41ad9ab485919d24af162021-11-18T08:13:48ZBiofilm modifies expression of ribonucleotide reductase genes in Escherichia coli.1932-620310.1371/journal.pone.0046350https://doaj.org/article/c17ec9e3a89d41ad9ab485919d24af162012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23050019/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Ribonucleotide reductase (RNR) is an essential enzyme for all living organisms since is the responsible for the last step in the synthesis of the four deoxyribonucleotides (dNTPs) necessary for DNA replication and repair. In this work, we have investigated the expression of the three-RNR classes (Ia, Ib and III) during Escherichia coli biofilm formation. We show the temporal and spatial importance of class Ib and III RNRs during this process in two different E. coli wild-type strains, the commensal MG1655 and the enteropathogenic and virulent E2348/69, the prototype for the enteropathogenic E. coli (EPEC). We have established that class Ib RNR, so far considered cryptic, play and important role during biofilm formation. The implication of this RNR class under the specific growth conditions of biofilm formation is discussed.Maria del Mar CendraAntonio JuárezEduard TorrentsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e46350 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria del Mar Cendra Antonio Juárez Eduard Torrents Biofilm modifies expression of ribonucleotide reductase genes in Escherichia coli.
description	Ribonucleotide reductase (RNR) is an essential enzyme for all living organisms since is the responsible for the last step in the synthesis of the four deoxyribonucleotides (dNTPs) necessary for DNA replication and repair. In this work, we have investigated the expression of the three-RNR classes (Ia, Ib and III) during Escherichia coli biofilm formation. We show the temporal and spatial importance of class Ib and III RNRs during this process in two different E. coli wild-type strains, the commensal MG1655 and the enteropathogenic and virulent E2348/69, the prototype for the enteropathogenic E. coli (EPEC). We have established that class Ib RNR, so far considered cryptic, play and important role during biofilm formation. The implication of this RNR class under the specific growth conditions of biofilm formation is discussed.
format	article
author	Maria del Mar Cendra Antonio Juárez Eduard Torrents
author_facet	Maria del Mar Cendra Antonio Juárez Eduard Torrents
author_sort	Maria del Mar Cendra
title	Biofilm modifies expression of ribonucleotide reductase genes in Escherichia coli.
title_short	Biofilm modifies expression of ribonucleotide reductase genes in Escherichia coli.
title_full	Biofilm modifies expression of ribonucleotide reductase genes in Escherichia coli.
title_fullStr	Biofilm modifies expression of ribonucleotide reductase genes in Escherichia coli.
title_full_unstemmed	Biofilm modifies expression of ribonucleotide reductase genes in Escherichia coli.
title_sort	biofilm modifies expression of ribonucleotide reductase genes in escherichia coli.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c17ec9e3a89d41ad9ab485919d24af16
work_keys_str_mv	AT mariadelmarcendra biofilmmodifiesexpressionofribonucleotidereductasegenesinescherichiacoli AT antoniojuarez biofilmmodifiesexpressionofribonucleotidereductasegenesinescherichiacoli AT eduardtorrents biofilmmodifiesexpressionofribonucleotidereductasegenesinescherichiacoli
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Biofilm modifies expression of ribonucleotide reductase genes in Escherichia coli.

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