An HLA-A*11:01-Binding Neoantigen from Mutated NPM1 as Target for TCR Gene Therapy in AML

An HLA-A*11:01-Binding Neoantigen from Mutated NPM1 as Target for TCR Gene Therapy in AML

Acute myeloid leukemia (AML) is a hematological malignancy caused by clonal expansion of myeloid progenitor cells. Most patients with AML respond to chemotherapy, but relapses often occur and infer a very poor prognosis. Thirty to thirty-five percent of AMLs carry a four base pair insertion in the n...

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Main Authors: Dyantha I. van der Lee, Georgia Koutsoumpli, Rogier M. Reijmers, Willy Honders, Rob C. M. de Jong, Dennis F. G. Remst, Tassilo L. A. Wachsmann, Renate S. Hagedoorn, Kees L. M. C. Franken, Michel G. D. Kester, Karl J. Harber, Lisanne M. Roelofsen, Annemiek M. Schouten, Arend Mulder, Jan W. Drijfhout, Hendrik Veelken, Peter A. van Veelen, Mirjam H. M. Heemskerk, Frederik Falkenburg, Marieke Griffioen
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
acute myeloid leukemia
neoantigens
cancer immunotherapy
T-cell receptor gene therapy
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/c17f00de15f74c7e976015e4595c0f2e
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https://doaj.org/article/c17f00de15f74c7e976015e4595c0f2e

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