Acupuncture and oxytocinergic system: The promising treatment for autism

Autism spectrum disorder (ASD) is a group of heterogeneous neurodevelopmental disorders characterized by impairments activities without efficient pharmacological therapies in social interaction, speech and stereotypic patterns. Clinical studies have shown the efficacy of acupuncture as an alternativ...

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Autores principales:	Su Tangfeng, Pei Lei
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	autism spectrum disorder oxytocin endocannabinoid serotonin dopamine nucleus accumbens ventral tegmental area Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c17f581187104e9fb399270d5854caf2
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spelling	oai:doaj.org-article:c17f581187104e9fb399270d5854caf22021-12-05T14:11:05ZAcupuncture and oxytocinergic system: The promising treatment for autism2081-693610.1515/tnsci-2021-0011https://doaj.org/article/c17f581187104e9fb399270d5854caf22021-02-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2021-0011https://doaj.org/toc/2081-6936Autism spectrum disorder (ASD) is a group of heterogeneous neurodevelopmental disorders characterized by impairments activities without efficient pharmacological therapies in social interaction, speech and stereotypic patterns. Clinical studies have shown the efficacy of acupuncture as an alternative therapy for autism. The effectiveness of acupuncture as an alternative treatment for autism has been demonstrated through clinical trials. However, the molecular mechanisms that underlie these effects remain unclear. Due to its profound pro-social, anxiolytic, stress management effects, and its potential use for the treatment of psychiatric disorders associated with altered socioemotional competence, oxytocin (OT) released from the hypothalamus has attracted considerable interest. In the past decade, a number of clinical and animal studies have shown that OT administration effectively reduces core symptoms of ASD, especially social behavior deficits. Recently, the endocannabinoid system has emerged as a promising target for the treatment of autism. OT was found to facilitate the endocannabinoid-mediated social reward processes in the nucleus accumbens of the mouse brain. Furthermore, serotonin and dopamine are involved in the reward response mediated by OT. In view of these findings, we conclude that acupuncture may produce therapeutic effects on autism by triggering the hypothalamic oxytocin system, which in turn activates the release of neurotransmitters such as endocannabinoids, dopamine and serotonin. This would be a valuable guide for further research on the mechanism of treatment of autism with acupuncture.Su TangfengPei LeiDe Gruyterarticleautism spectrum disorderoxytocinendocannabinoidserotonindopaminenucleus accumbensventral tegmental areaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 12, Iss 1, Pp 96-102 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism spectrum disorder oxytocin endocannabinoid serotonin dopamine nucleus accumbens ventral tegmental area Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	autism spectrum disorder oxytocin endocannabinoid serotonin dopamine nucleus accumbens ventral tegmental area Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Su Tangfeng Pei Lei Acupuncture and oxytocinergic system: The promising treatment for autism
description	Autism spectrum disorder (ASD) is a group of heterogeneous neurodevelopmental disorders characterized by impairments activities without efficient pharmacological therapies in social interaction, speech and stereotypic patterns. Clinical studies have shown the efficacy of acupuncture as an alternative therapy for autism. The effectiveness of acupuncture as an alternative treatment for autism has been demonstrated through clinical trials. However, the molecular mechanisms that underlie these effects remain unclear. Due to its profound pro-social, anxiolytic, stress management effects, and its potential use for the treatment of psychiatric disorders associated with altered socioemotional competence, oxytocin (OT) released from the hypothalamus has attracted considerable interest. In the past decade, a number of clinical and animal studies have shown that OT administration effectively reduces core symptoms of ASD, especially social behavior deficits. Recently, the endocannabinoid system has emerged as a promising target for the treatment of autism. OT was found to facilitate the endocannabinoid-mediated social reward processes in the nucleus accumbens of the mouse brain. Furthermore, serotonin and dopamine are involved in the reward response mediated by OT. In view of these findings, we conclude that acupuncture may produce therapeutic effects on autism by triggering the hypothalamic oxytocin system, which in turn activates the release of neurotransmitters such as endocannabinoids, dopamine and serotonin. This would be a valuable guide for further research on the mechanism of treatment of autism with acupuncture.
format	article
author	Su Tangfeng Pei Lei
author_facet	Su Tangfeng Pei Lei
author_sort	Su Tangfeng
title	Acupuncture and oxytocinergic system: The promising treatment for autism
title_short	Acupuncture and oxytocinergic system: The promising treatment for autism
title_full	Acupuncture and oxytocinergic system: The promising treatment for autism
title_fullStr	Acupuncture and oxytocinergic system: The promising treatment for autism
title_full_unstemmed	Acupuncture and oxytocinergic system: The promising treatment for autism
title_sort	acupuncture and oxytocinergic system: the promising treatment for autism
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/c17f581187104e9fb399270d5854caf2
work_keys_str_mv	AT sutangfeng acupunctureandoxytocinergicsystemthepromisingtreatmentforautism AT peilei acupunctureandoxytocinergicsystemthepromisingtreatmentforautism
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Acupuncture and oxytocinergic system: The promising treatment for autism

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