An efficient synthesis of furan-3(2<italic toggle="yes">H</italic>)-imine scaffold from alkynones

A novel efficient method to generate spiro furan-3(2H)-imine derivatives is established by the reaction between the α,β-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to pr...

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Autores principales:	Anas J. Rasras, Ihsan A. Shehadi, Eyad A. Younes, Da'san M. M. Jaradat, Raed A. AlQawasmeh
Formato:	article
Lenguaje:	EN
Publicado:	The Royal Society 2021
Materias:	efficient synthesis furan-3(2H)-imine scaffold alkynones authors Science Q
Acceso en línea:	https://doaj.org/article/c18520e5cda64a3c9492fc62c99f52ea
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spelling	oai:doaj.org-article:c18520e5cda64a3c9492fc62c99f52ea2021-11-24T08:05:48ZAn efficient synthesis of furan-3(2<italic toggle="yes">H</italic>)-imine scaffold from alkynones10.1098/rsos.2111452054-5703https://doaj.org/article/c18520e5cda64a3c9492fc62c99f52ea2021-11-01T00:00:00Zhttps://royalsocietypublishing.org/doi/10.1098/rsos.211145https://doaj.org/toc/2054-5703A novel efficient method to generate spiro furan-3(2H)-imine derivatives is established by the reaction between the α,β-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2H)-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS).Anas J. RasrasIhsan A. ShehadiEyad A. YounesDa'san M. M. JaradatRaed A. AlQawasmehThe Royal Societyarticleefficientsynthesisfuran-3(2H)-iminescaffoldalkynonesauthorsScienceQENRoyal Society Open Science, Vol 8, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	efficient synthesis furan-3(2H)-imine scaffold alkynones authors Science Q
spellingShingle	efficient synthesis furan-3(2H)-imine scaffold alkynones authors Science Q Anas J. Rasras Ihsan A. Shehadi Eyad A. Younes Da'san M. M. Jaradat Raed A. AlQawasmeh An efficient synthesis of furan-3(2<italic toggle="yes">H</italic>)-imine scaffold from alkynones
description	A novel efficient method to generate spiro furan-3(2H)-imine derivatives is established by the reaction between the α,β-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2H)-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS).
format	article
author	Anas J. Rasras Ihsan A. Shehadi Eyad A. Younes Da'san M. M. Jaradat Raed A. AlQawasmeh
author_facet	Anas J. Rasras Ihsan A. Shehadi Eyad A. Younes Da'san M. M. Jaradat Raed A. AlQawasmeh
author_sort	Anas J. Rasras
title	An efficient synthesis of furan-3(2<italic toggle="yes">H</italic>)-imine scaffold from alkynones
title_short	An efficient synthesis of furan-3(2<italic toggle="yes">H</italic>)-imine scaffold from alkynones
title_full	An efficient synthesis of furan-3(2<italic toggle="yes">H</italic>)-imine scaffold from alkynones
title_fullStr	An efficient synthesis of furan-3(2<italic toggle="yes">H</italic>)-imine scaffold from alkynones
title_full_unstemmed	An efficient synthesis of furan-3(2<italic toggle="yes">H</italic>)-imine scaffold from alkynones
title_sort	efficient synthesis of furan-3(2<italic toggle="yes">h</italic>)-imine scaffold from alkynones
publisher	The Royal Society
publishDate	2021
url	https://doaj.org/article/c18520e5cda64a3c9492fc62c99f52ea
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An efficient synthesis of furan-3(2<italic toggle="yes">H</italic>)-imine scaffold from alkynones

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