Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor.

Understanding how protein structures and functions have diversified is a central goal in molecular evolution. Surveys of very divergent proteins from model organisms, however, are often insufficient to determine the features of ancestral proteins and to reveal the evolutionary events that yielded ex...

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Bibliographic Details
Main Authors: Jamie T Bridgham, Geeta N Eick, Claire Larroux, Kirti Deshpande, Michael J Harms, Marie E A Gauthier, Eric A Ortlund, Bernard M Degnan, Joseph W Thornton
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
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Online Access:https://doaj.org/article/c185903708334990b97c10da23550c62
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