Comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population.

<h4>Background</h4>To compare diabetes risk assessment tools in estimating risk of developing type 2 diabetes (T2DM) and to evaluate cardiometabolic risk profiles in a middle-aged Irish population.<h4>Methods</h4>Future risk of developing T2DM was estimated using 7 risk score...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Catherine M Phillips, Patricia M Kearney, Vera J McCarthy, Janas M Harrington, Anthony P Fitzgerald, Ivan J Perry
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c18844930f824606a7b33fc9f528e340
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c18844930f824606a7b33fc9f528e340
record_format	dspace
spelling	oai:doaj.org-article:c18844930f824606a7b33fc9f528e3402021-11-18T08:46:52ZComparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population.1932-620310.1371/journal.pone.0078950https://doaj.org/article/c18844930f824606a7b33fc9f528e3402013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24236074/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To compare diabetes risk assessment tools in estimating risk of developing type 2 diabetes (T2DM) and to evaluate cardiometabolic risk profiles in a middle-aged Irish population.<h4>Methods</h4>Future risk of developing T2DM was estimated using 7 risk scores, including clinical measures with or without anthropometric, biological and lifestyle data, in the cross-sectional Mitchelstown cohort of 2,047 middle-aged men and women. Cardiometabolic phenotypes including markers of glucose metabolism, inflammatory and lipid profiles were determined.<h4>Results</h4>Estimates of subjects at risk for developing T2DM varied considerably according to the risk assessment tool used (0.3% to 20%), with higher proportions of males at risk (0-29.2% vs. 0.1-13.4%, for men and women, respectively). Extrapolated to the Irish population of similar age, the overall number of adults at high risk of developing T2DM ranges from 3,378 to 236,632. Numbers of non-optimal metabolic features were generally greater among those at high risk of developing T2DM. However, cardiometabolic profile characterisation revealed that only those classified at high risk by the Griffin (UK Cambridge) score displayed a more pro-inflammatory, obese, hypertensive, dysglycaemic and insulin resistant metabolic phenotype.<h4>Conclusions</h4>Most diabetes risk scores examined offer limited ability to identify subjects with metabolic abnormalities and at risk of developing T2DM. Our results highlight the need to validate diabetes risk scoring tools for each population studied and the potential for developing an Irish diabetes risk score, which may help to promote self awareness and identify high risk individuals and diabetes hot spots for targeted public health interventions.Catherine M PhillipsPatricia M KearneyVera J McCarthyJanas M HarringtonAnthony P FitzgeraldIvan J PerryPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e78950 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Catherine M Phillips Patricia M Kearney Vera J McCarthy Janas M Harrington Anthony P Fitzgerald Ivan J Perry Comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population.
description	<h4>Background</h4>To compare diabetes risk assessment tools in estimating risk of developing type 2 diabetes (T2DM) and to evaluate cardiometabolic risk profiles in a middle-aged Irish population.<h4>Methods</h4>Future risk of developing T2DM was estimated using 7 risk scores, including clinical measures with or without anthropometric, biological and lifestyle data, in the cross-sectional Mitchelstown cohort of 2,047 middle-aged men and women. Cardiometabolic phenotypes including markers of glucose metabolism, inflammatory and lipid profiles were determined.<h4>Results</h4>Estimates of subjects at risk for developing T2DM varied considerably according to the risk assessment tool used (0.3% to 20%), with higher proportions of males at risk (0-29.2% vs. 0.1-13.4%, for men and women, respectively). Extrapolated to the Irish population of similar age, the overall number of adults at high risk of developing T2DM ranges from 3,378 to 236,632. Numbers of non-optimal metabolic features were generally greater among those at high risk of developing T2DM. However, cardiometabolic profile characterisation revealed that only those classified at high risk by the Griffin (UK Cambridge) score displayed a more pro-inflammatory, obese, hypertensive, dysglycaemic and insulin resistant metabolic phenotype.<h4>Conclusions</h4>Most diabetes risk scores examined offer limited ability to identify subjects with metabolic abnormalities and at risk of developing T2DM. Our results highlight the need to validate diabetes risk scoring tools for each population studied and the potential for developing an Irish diabetes risk score, which may help to promote self awareness and identify high risk individuals and diabetes hot spots for targeted public health interventions.
format	article
author	Catherine M Phillips Patricia M Kearney Vera J McCarthy Janas M Harrington Anthony P Fitzgerald Ivan J Perry
author_facet	Catherine M Phillips Patricia M Kearney Vera J McCarthy Janas M Harrington Anthony P Fitzgerald Ivan J Perry
author_sort	Catherine M Phillips
title	Comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population.
title_short	Comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population.
title_full	Comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population.
title_fullStr	Comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population.
title_full_unstemmed	Comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population.
title_sort	comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged irish population.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c18844930f824606a7b33fc9f528e340
work_keys_str_mv	AT catherinemphillips comparisonofdiabetesriskscoreestimatesandcardiometabolicriskprofilesinamiddleagedirishpopulation AT patriciamkearney comparisonofdiabetesriskscoreestimatesandcardiometabolicriskprofilesinamiddleagedirishpopulation AT verajmccarthy comparisonofdiabetesriskscoreestimatesandcardiometabolicriskprofilesinamiddleagedirishpopulation AT janasmharrington comparisonofdiabetesriskscoreestimatesandcardiometabolicriskprofilesinamiddleagedirishpopulation AT anthonypfitzgerald comparisonofdiabetesriskscoreestimatesandcardiometabolicriskprofilesinamiddleagedirishpopulation AT ivanjperry comparisonofdiabetesriskscoreestimatesandcardiometabolicriskprofilesinamiddleagedirishpopulation
_version_	1718421347617472512

Comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population.

Ejemplares similares