Population-based identification and temporal trend of children with primary nephrotic syndrome: The Kaiser Permanente nephrotic syndrome study.

<h4>Introduction</h4>Limited population-based data exist about children with primary nephrotic syndrome (NS).<h4>Methods</h4>We identified a cohort of children with primary NS receiving care in Kaiser Permanente Northern California, an integrated healthcare delivery system ca...

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Autores principales: Rishi V Parikh, Thida C Tan, Dongjie Fan, David Law, Anne S Salyer, Leonid Yankulin, Janet M Wojcicki, Sijie Zheng, Juan D Ordonez, Glenn M Chertow, Farzien Khoshniat-Rad, Jingrong Yang, Alan S Go
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Publicado: Public Library of Science (PLoS) 2021
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spelling oai:doaj.org-article:c188e1e3a35c4e238485a615ab6c890d2021-12-02T20:16:58ZPopulation-based identification and temporal trend of children with primary nephrotic syndrome: The Kaiser Permanente nephrotic syndrome study.1932-620310.1371/journal.pone.0257674https://doaj.org/article/c188e1e3a35c4e238485a615ab6c890d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257674https://doaj.org/toc/1932-6203<h4>Introduction</h4>Limited population-based data exist about children with primary nephrotic syndrome (NS).<h4>Methods</h4>We identified a cohort of children with primary NS receiving care in Kaiser Permanente Northern California, an integrated healthcare delivery system caring for >750,000 children. We identified all children <18 years between 1996 and 2012 who had nephrotic range proteinuria (urine ACR>3500 mg/g, urine PCR>3.5 mg/mg, 24-hour urine protein>3500 mg or urine dipstick>300 mg/dL) in laboratory databases or a diagnosis of NS in electronic health records. Nephrologists reviewed health records for clinical presentation and laboratory and biopsy results to confirm primary NS.<h4>Results</h4>Among 365 cases of confirmed NS, 179 had confirmed primary NS attributed to presumed minimal change disease (MCD) (72%), focal segmental glomerulosclerosis (FSGS) (23%) or membranous nephropathy (MN) (5%). The overall incidence of primary NS was 1.47 (95% Confidence Interval:1.27-1.70) per 100,000 person-years. Biopsy data were available in 40% of cases. Median age for patients with primary NS was 6.9 (interquartile range:3.7 to 12.9) years, 43% were female and 26% were white, 13% black, 17% Asian/Pacific Islander, and 32% Hispanic.<h4>Conclusion</h4>This population-based identification of children with primary NS leveraging electronic health records can provide a unique approach and platform for describing the natural history of NS and identifying determinants of outcomes in children with primary NS.Rishi V ParikhThida C TanDongjie FanDavid LawAnne S SalyerLeonid YankulinJanet M WojcickiSijie ZhengJuan D OrdonezGlenn M ChertowFarzien Khoshniat-RadJingrong YangAlan S GoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0257674 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Rishi V Parikh
Thida C Tan
Dongjie Fan
David Law
Anne S Salyer
Leonid Yankulin
Janet M Wojcicki
Sijie Zheng
Juan D Ordonez
Glenn M Chertow
Farzien Khoshniat-Rad
Jingrong Yang
Alan S Go
Population-based identification and temporal trend of children with primary nephrotic syndrome: The Kaiser Permanente nephrotic syndrome study.
description <h4>Introduction</h4>Limited population-based data exist about children with primary nephrotic syndrome (NS).<h4>Methods</h4>We identified a cohort of children with primary NS receiving care in Kaiser Permanente Northern California, an integrated healthcare delivery system caring for >750,000 children. We identified all children <18 years between 1996 and 2012 who had nephrotic range proteinuria (urine ACR>3500 mg/g, urine PCR>3.5 mg/mg, 24-hour urine protein>3500 mg or urine dipstick>300 mg/dL) in laboratory databases or a diagnosis of NS in electronic health records. Nephrologists reviewed health records for clinical presentation and laboratory and biopsy results to confirm primary NS.<h4>Results</h4>Among 365 cases of confirmed NS, 179 had confirmed primary NS attributed to presumed minimal change disease (MCD) (72%), focal segmental glomerulosclerosis (FSGS) (23%) or membranous nephropathy (MN) (5%). The overall incidence of primary NS was 1.47 (95% Confidence Interval:1.27-1.70) per 100,000 person-years. Biopsy data were available in 40% of cases. Median age for patients with primary NS was 6.9 (interquartile range:3.7 to 12.9) years, 43% were female and 26% were white, 13% black, 17% Asian/Pacific Islander, and 32% Hispanic.<h4>Conclusion</h4>This population-based identification of children with primary NS leveraging electronic health records can provide a unique approach and platform for describing the natural history of NS and identifying determinants of outcomes in children with primary NS.
format article
author Rishi V Parikh
Thida C Tan
Dongjie Fan
David Law
Anne S Salyer
Leonid Yankulin
Janet M Wojcicki
Sijie Zheng
Juan D Ordonez
Glenn M Chertow
Farzien Khoshniat-Rad
Jingrong Yang
Alan S Go
author_facet Rishi V Parikh
Thida C Tan
Dongjie Fan
David Law
Anne S Salyer
Leonid Yankulin
Janet M Wojcicki
Sijie Zheng
Juan D Ordonez
Glenn M Chertow
Farzien Khoshniat-Rad
Jingrong Yang
Alan S Go
author_sort Rishi V Parikh
title Population-based identification and temporal trend of children with primary nephrotic syndrome: The Kaiser Permanente nephrotic syndrome study.
title_short Population-based identification and temporal trend of children with primary nephrotic syndrome: The Kaiser Permanente nephrotic syndrome study.
title_full Population-based identification and temporal trend of children with primary nephrotic syndrome: The Kaiser Permanente nephrotic syndrome study.
title_fullStr Population-based identification and temporal trend of children with primary nephrotic syndrome: The Kaiser Permanente nephrotic syndrome study.
title_full_unstemmed Population-based identification and temporal trend of children with primary nephrotic syndrome: The Kaiser Permanente nephrotic syndrome study.
title_sort population-based identification and temporal trend of children with primary nephrotic syndrome: the kaiser permanente nephrotic syndrome study.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/c188e1e3a35c4e238485a615ab6c890d
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