Intraocular pressure and choroidal thickness postural changes in multiple system atrophy and Parkinson’s disease

Abstract To evaluate intraocular pressure (IOP) and choroidal thickness (ChT) postural changes in multiple system atrophy (MSA), Parkinson’s disease (PD) patients and healthy controls (HC). 20 MSA patients, 21 PD patients and 14 HC, were examined. All subjects underwent a complete examination, inclu...

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Autores principales:	Maddalena De Bernardo, Giulio Salerno, Marco Gioia, Luigi Capasso, Maria Claudia Russillo, Marina Picillo, Roberto Erro, Marianna Amboni, Paolo Barone, Nicola Rosa, Maria Teresa Pellecchia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c18995ed948e4798b693121e2e15dc55
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spelling	oai:doaj.org-article:c18995ed948e4798b693121e2e15dc552021-12-02T17:39:31ZIntraocular pressure and choroidal thickness postural changes in multiple system atrophy and Parkinson’s disease10.1038/s41598-021-88250-32045-2322https://doaj.org/article/c18995ed948e4798b693121e2e15dc552021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88250-3https://doaj.org/toc/2045-2322Abstract To evaluate intraocular pressure (IOP) and choroidal thickness (ChT) postural changes in multiple system atrophy (MSA), Parkinson’s disease (PD) patients and healthy controls (HC). 20 MSA patients, 21 PD patients and 14 HC, were examined. All subjects underwent a complete examination, including corneal thickness, ChT, IOP and axial length (AL) measurements. IOP measurement was performed in supine, sitting, and standing positions, whereas ChT in sitting and standing positions. Supine to standing IOP variations were significantly higher in MSA vs PD(p = 0.01) and in MSA vs HC (p < 0.0001), whereas no significant differences were observed between PD and HC (p = 0.397). Mean sub-foveal ChT in MSA was 240 ± 92 μm in sitting position, and 215 ± 94 μm in standing position with a significant reduction (p = 0.008). Mean sub-foveal ChT in PD was 258 ± 79 μm in sitting position, and 259 ± 76 μm in standing position (p = 0.887). In HC it was 244 ± 36 μm in sitting position, and 256 ± 37 μm in standing position with a significant increase (p = 0.007). The significant IOP and ChT postural changes can be considered additional hallmarks of autonomic dysfunction in MSA and further studies are needed to consider them as biomarkers in the differential diagnosis with PD.Maddalena De BernardoGiulio SalernoMarco GioiaLuigi CapassoMaria Claudia RussilloMarina PicilloRoberto ErroMarianna AmboniPaolo BaroneNicola RosaMaria Teresa PellecchiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maddalena De Bernardo Giulio Salerno Marco Gioia Luigi Capasso Maria Claudia Russillo Marina Picillo Roberto Erro Marianna Amboni Paolo Barone Nicola Rosa Maria Teresa Pellecchia Intraocular pressure and choroidal thickness postural changes in multiple system atrophy and Parkinson’s disease
description	Abstract To evaluate intraocular pressure (IOP) and choroidal thickness (ChT) postural changes in multiple system atrophy (MSA), Parkinson’s disease (PD) patients and healthy controls (HC). 20 MSA patients, 21 PD patients and 14 HC, were examined. All subjects underwent a complete examination, including corneal thickness, ChT, IOP and axial length (AL) measurements. IOP measurement was performed in supine, sitting, and standing positions, whereas ChT in sitting and standing positions. Supine to standing IOP variations were significantly higher in MSA vs PD(p = 0.01) and in MSA vs HC (p < 0.0001), whereas no significant differences were observed between PD and HC (p = 0.397). Mean sub-foveal ChT in MSA was 240 ± 92 μm in sitting position, and 215 ± 94 μm in standing position with a significant reduction (p = 0.008). Mean sub-foveal ChT in PD was 258 ± 79 μm in sitting position, and 259 ± 76 μm in standing position (p = 0.887). In HC it was 244 ± 36 μm in sitting position, and 256 ± 37 μm in standing position with a significant increase (p = 0.007). The significant IOP and ChT postural changes can be considered additional hallmarks of autonomic dysfunction in MSA and further studies are needed to consider them as biomarkers in the differential diagnosis with PD.
format	article
author	Maddalena De Bernardo Giulio Salerno Marco Gioia Luigi Capasso Maria Claudia Russillo Marina Picillo Roberto Erro Marianna Amboni Paolo Barone Nicola Rosa Maria Teresa Pellecchia
author_facet	Maddalena De Bernardo Giulio Salerno Marco Gioia Luigi Capasso Maria Claudia Russillo Marina Picillo Roberto Erro Marianna Amboni Paolo Barone Nicola Rosa Maria Teresa Pellecchia
author_sort	Maddalena De Bernardo
title	Intraocular pressure and choroidal thickness postural changes in multiple system atrophy and Parkinson’s disease
title_short	Intraocular pressure and choroidal thickness postural changes in multiple system atrophy and Parkinson’s disease
title_full	Intraocular pressure and choroidal thickness postural changes in multiple system atrophy and Parkinson’s disease
title_fullStr	Intraocular pressure and choroidal thickness postural changes in multiple system atrophy and Parkinson’s disease
title_full_unstemmed	Intraocular pressure and choroidal thickness postural changes in multiple system atrophy and Parkinson’s disease
title_sort	intraocular pressure and choroidal thickness postural changes in multiple system atrophy and parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c18995ed948e4798b693121e2e15dc55
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Intraocular pressure and choroidal thickness postural changes in multiple system atrophy and Parkinson’s disease

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