Knee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis

Abstract The aim of this study was to explore the existence of subgroups in a cohort of people with knee osteoarthritis (OA) based upon data from multiple pain-related variables and to profile identified clusters according to levels of pain intensity and knee-related disability. Three hundred and th...

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Autores principales:	Tomohiko Nishigami, So Tanaka, Akira Mibu, Ryota Imai, Benedict Martin Wand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c18ce688d1664444a2bbc5a75f5b336d
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spelling	oai:doaj.org-article:c18ce688d1664444a2bbc5a75f5b336d2021-12-02T11:36:36ZKnee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis10.1038/s41598-021-85307-12045-2322https://doaj.org/article/c18ce688d1664444a2bbc5a75f5b336d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85307-1https://doaj.org/toc/2045-2322Abstract The aim of this study was to explore the existence of subgroups in a cohort of people with knee osteoarthritis (OA) based upon data from multiple pain-related variables and to profile identified clusters according to levels of pain intensity and knee-related disability. Three hundred and three people with knee OA were recruited. Latent profile analysis was used to confirm the optimal number of knee OA subgroups. Body mass index, radiographic knee OA severity, pain catastrophizing, pain related self-efficacy, and knee specific self-perception, were incorporated into the model. Cluster, demographic and clinical variables were compared between the resulting classes. Four distinct classes were identified. Cluster 1 (28.7%) represented early radiographic OA, and moderate pain intensity, disability and cognitive and perceptual dysfunction. Cluster 2 (18.8%) showed advanced radiographic OA, and moderate pain intensity, disability and cognitive and perceptual dysfunction. Cluster 3 (34.3%) represented various levels of radiographic OA, and the lowest pain intensity, disability and cognitive and perceptual dysfunction. Cluster 4 (18.1%) represented various levels of radiographic OA, the highest disability and cognitive and perceptual dysfunction. Considering cognitive factors and disturbed body perception may help to explain the phenomenon of the discrepancy between the knee-related disability and the severity of radiographic knee OA.Tomohiko NishigamiSo TanakaAkira MibuRyota ImaiBenedict Martin WandNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomohiko Nishigami So Tanaka Akira Mibu Ryota Imai Benedict Martin Wand Knee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis
description	Abstract The aim of this study was to explore the existence of subgroups in a cohort of people with knee osteoarthritis (OA) based upon data from multiple pain-related variables and to profile identified clusters according to levels of pain intensity and knee-related disability. Three hundred and three people with knee OA were recruited. Latent profile analysis was used to confirm the optimal number of knee OA subgroups. Body mass index, radiographic knee OA severity, pain catastrophizing, pain related self-efficacy, and knee specific self-perception, were incorporated into the model. Cluster, demographic and clinical variables were compared between the resulting classes. Four distinct classes were identified. Cluster 1 (28.7%) represented early radiographic OA, and moderate pain intensity, disability and cognitive and perceptual dysfunction. Cluster 2 (18.8%) showed advanced radiographic OA, and moderate pain intensity, disability and cognitive and perceptual dysfunction. Cluster 3 (34.3%) represented various levels of radiographic OA, and the lowest pain intensity, disability and cognitive and perceptual dysfunction. Cluster 4 (18.1%) represented various levels of radiographic OA, the highest disability and cognitive and perceptual dysfunction. Considering cognitive factors and disturbed body perception may help to explain the phenomenon of the discrepancy between the knee-related disability and the severity of radiographic knee OA.
format	article
author	Tomohiko Nishigami So Tanaka Akira Mibu Ryota Imai Benedict Martin Wand
author_facet	Tomohiko Nishigami So Tanaka Akira Mibu Ryota Imai Benedict Martin Wand
author_sort	Tomohiko Nishigami
title	Knee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis
title_short	Knee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis
title_full	Knee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis
title_fullStr	Knee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis
title_full_unstemmed	Knee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis
title_sort	knee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c18ce688d1664444a2bbc5a75f5b336d
work_keys_str_mv	AT tomohikonishigami kneerelateddisabilitywaslargelyinfluencedbycognitivefactorsanddisturbedbodyperceptioninkneeosteoarthritis AT sotanaka kneerelateddisabilitywaslargelyinfluencedbycognitivefactorsanddisturbedbodyperceptioninkneeosteoarthritis AT akiramibu kneerelateddisabilitywaslargelyinfluencedbycognitivefactorsanddisturbedbodyperceptioninkneeosteoarthritis AT ryotaimai kneerelateddisabilitywaslargelyinfluencedbycognitivefactorsanddisturbedbodyperceptioninkneeosteoarthritis AT benedictmartinwand kneerelateddisabilitywaslargelyinfluencedbycognitivefactorsanddisturbedbodyperceptioninkneeosteoarthritis
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Knee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis

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