MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes
The membrane-associated RING-CH (MARCH) proteins are E3 ligases regulating stability of plasma membrane (PM) proteins. Here, Liu et al. show that MARCH8 suppresses Influenza A virus infection in vitro and in vivo through redirecting M2 protein from the PM to lysosomes for degradation.
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Nature Portfolio
2021
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oai:doaj.org-article:c191a477fefc49b2bfbefa0ae5c8f1e12021-12-02T16:26:25ZMARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes10.1038/s41467-021-24724-22041-1723https://doaj.org/article/c191a477fefc49b2bfbefa0ae5c8f1e12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24724-2https://doaj.org/toc/2041-1723The membrane-associated RING-CH (MARCH) proteins are E3 ligases regulating stability of plasma membrane (PM) proteins. Here, Liu et al. show that MARCH8 suppresses Influenza A virus infection in vitro and in vivo through redirecting M2 protein from the PM to lysosomes for degradation.Xiaoman LiuFengwen XuLili RenFei ZhaoYu HuangLiang WeiYingying WangConghui WangZhangling FanShan MeiJingdong SongZhendong ZhaoShan CenChen LiangJianwei WangFei GuoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Xiaoman Liu Fengwen Xu Lili Ren Fei Zhao Yu Huang Liang Wei Yingying Wang Conghui Wang Zhangling Fan Shan Mei Jingdong Song Zhendong Zhao Shan Cen Chen Liang Jianwei Wang Fei Guo MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes |
| description |
The membrane-associated RING-CH (MARCH) proteins are E3 ligases regulating stability of plasma membrane (PM) proteins. Here, Liu et al. show that MARCH8 suppresses Influenza A virus infection in vitro and in vivo through redirecting M2 protein from the PM to lysosomes for degradation. |
| format |
article |
| author |
Xiaoman Liu Fengwen Xu Lili Ren Fei Zhao Yu Huang Liang Wei Yingying Wang Conghui Wang Zhangling Fan Shan Mei Jingdong Song Zhendong Zhao Shan Cen Chen Liang Jianwei Wang Fei Guo |
| author_facet |
Xiaoman Liu Fengwen Xu Lili Ren Fei Zhao Yu Huang Liang Wei Yingying Wang Conghui Wang Zhangling Fan Shan Mei Jingdong Song Zhendong Zhao Shan Cen Chen Liang Jianwei Wang Fei Guo |
| author_sort |
Xiaoman Liu |
| title |
MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes |
| title_short |
MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes |
| title_full |
MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes |
| title_fullStr |
MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes |
| title_full_unstemmed |
MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes |
| title_sort |
march8 inhibits influenza a virus infection by targeting viral m2 protein for ubiquitination-dependent degradation in lysosomes |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c191a477fefc49b2bfbefa0ae5c8f1e1 |
| work_keys_str_mv |
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1718384078960459776 |