Neuropsychological outcomes of children with Optic Pathway Glioma

Abstract Optic Pathway Glioma (OPG) is a relatively common brain tumour in childhood; however, there is scarce understanding of neuropsychological sequelae in these survivors. In this study, 12 children with diagnosis of OPG before 6 years of age received a comprehensive standardised assessment of v...

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Autores principales:	Chiara Papini, Robert A. Dineen, David A. Walker, Shery Thomas, Nicola J. Pitchford
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c1953fa583054447bce55006136d6a9b
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spelling	oai:doaj.org-article:c1953fa583054447bce55006136d6a9b2021-12-02T16:23:09ZNeuropsychological outcomes of children with Optic Pathway Glioma10.1038/s41598-020-59896-22045-2322https://doaj.org/article/c1953fa583054447bce55006136d6a9b2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-59896-2https://doaj.org/toc/2045-2322Abstract Optic Pathway Glioma (OPG) is a relatively common brain tumour in childhood; however, there is scarce understanding of neuropsychological sequelae in these survivors. In this study, 12 children with diagnosis of OPG before 6 years of age received a comprehensive standardised assessment of visual perception, general intelligence and academic achievement, using adjustments to visual materials of the tests, to examine the extent of concurrent impairment in these functional domains. Information about vision, clinical and socio-demographic factors were extracted from medical records to assess the associations of neuropsychological outcomes with clinical and socio-demographic factors. Children with OPG exhibited high within-patient variability and moderate group-level impairment compared to test norms. Visual perception was the most impaired domain, while scholastic progression was age-appropriate overall. For cognition, core verbal and visuo-spatial reasoning skills were intact, whereas deficits were found in working memory and processing speed. Visual function was associated with tasks that rely on visual input. Children with OPG are at moderate risk of neuropsychological impairment, especially for visual perception and cognitive proficiency. Future research should elucidate further the relative contribution of vision loss and neurofibromatosis type 1 co-diagnosis within a large sample.Chiara PapiniRobert A. DineenDavid A. WalkerShery ThomasNicola J. PitchfordNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chiara Papini Robert A. Dineen David A. Walker Shery Thomas Nicola J. Pitchford Neuropsychological outcomes of children with Optic Pathway Glioma
description	Abstract Optic Pathway Glioma (OPG) is a relatively common brain tumour in childhood; however, there is scarce understanding of neuropsychological sequelae in these survivors. In this study, 12 children with diagnosis of OPG before 6 years of age received a comprehensive standardised assessment of visual perception, general intelligence and academic achievement, using adjustments to visual materials of the tests, to examine the extent of concurrent impairment in these functional domains. Information about vision, clinical and socio-demographic factors were extracted from medical records to assess the associations of neuropsychological outcomes with clinical and socio-demographic factors. Children with OPG exhibited high within-patient variability and moderate group-level impairment compared to test norms. Visual perception was the most impaired domain, while scholastic progression was age-appropriate overall. For cognition, core verbal and visuo-spatial reasoning skills were intact, whereas deficits were found in working memory and processing speed. Visual function was associated with tasks that rely on visual input. Children with OPG are at moderate risk of neuropsychological impairment, especially for visual perception and cognitive proficiency. Future research should elucidate further the relative contribution of vision loss and neurofibromatosis type 1 co-diagnosis within a large sample.
format	article
author	Chiara Papini Robert A. Dineen David A. Walker Shery Thomas Nicola J. Pitchford
author_facet	Chiara Papini Robert A. Dineen David A. Walker Shery Thomas Nicola J. Pitchford
author_sort	Chiara Papini
title	Neuropsychological outcomes of children with Optic Pathway Glioma
title_short	Neuropsychological outcomes of children with Optic Pathway Glioma
title_full	Neuropsychological outcomes of children with Optic Pathway Glioma
title_fullStr	Neuropsychological outcomes of children with Optic Pathway Glioma
title_full_unstemmed	Neuropsychological outcomes of children with Optic Pathway Glioma
title_sort	neuropsychological outcomes of children with optic pathway glioma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c1953fa583054447bce55006136d6a9b
work_keys_str_mv	AT chiarapapini neuropsychologicaloutcomesofchildrenwithopticpathwayglioma AT robertadineen neuropsychologicaloutcomesofchildrenwithopticpathwayglioma AT davidawalker neuropsychologicaloutcomesofchildrenwithopticpathwayglioma AT sherythomas neuropsychologicaloutcomesofchildrenwithopticpathwayglioma AT nicolajpitchford neuropsychologicaloutcomesofchildrenwithopticpathwayglioma
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Neuropsychological outcomes of children with Optic Pathway Glioma

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