The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons

The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons

Spike-frequency adaptation in thalamocortical (TC) neurons is important for sensory transmission though the underlying mechanisms are not fully understood. Here, the authors identify a role for the calcium-activated chloride channel, ANO2, in mediating TC spiking adaptations and visceral pain respon...

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Autores principales: Go Eun Ha, Jaekwang Lee, Hankyul Kwak, Kiyeong Song, Jea Kwon, Soon-Young Jung, Joohyeon Hong, Gyeong-Eon Chang, Eun Mi Hwang, Hee-Sup Shin, C. Justin Lee, Eunji Cheong
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/c19edda13452426aba259acb5f3878f4
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spelling oai:doaj.org-article:c19edda13452426aba259acb5f3878f42021-12-02T16:58:11ZThe Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons10.1038/ncomms137912041-1723https://doaj.org/article/c19edda13452426aba259acb5f3878f42016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13791https://doaj.org/toc/2041-1723Spike-frequency adaptation in thalamocortical (TC) neurons is important for sensory transmission though the underlying mechanisms are not fully understood. Here, the authors identify a role for the calcium-activated chloride channel, ANO2, in mediating TC spiking adaptations and visceral pain response.Go Eun HaJaekwang LeeHankyul KwakKiyeong SongJea KwonSoon-Young JungJoohyeon HongGyeong-Eon ChangEun Mi HwangHee-Sup ShinC. Justin LeeEunji CheongNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Go Eun Ha
Jaekwang Lee
Hankyul Kwak
Kiyeong Song
Jea Kwon
Soon-Young Jung
Joohyeon Hong
Gyeong-Eon Chang
Eun Mi Hwang
Hee-Sup Shin
C. Justin Lee
Eunji Cheong
The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons
description Spike-frequency adaptation in thalamocortical (TC) neurons is important for sensory transmission though the underlying mechanisms are not fully understood. Here, the authors identify a role for the calcium-activated chloride channel, ANO2, in mediating TC spiking adaptations and visceral pain response.
format article
author Go Eun Ha
Jaekwang Lee
Hankyul Kwak
Kiyeong Song
Jea Kwon
Soon-Young Jung
Joohyeon Hong
Gyeong-Eon Chang
Eun Mi Hwang
Hee-Sup Shin
C. Justin Lee
Eunji Cheong
author_facet Go Eun Ha
Jaekwang Lee
Hankyul Kwak
Kiyeong Song
Jea Kwon
Soon-Young Jung
Joohyeon Hong
Gyeong-Eon Chang
Eun Mi Hwang
Hee-Sup Shin
C. Justin Lee
Eunji Cheong
author_sort Go Eun Ha
title The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons
title_short The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons
title_full The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons
title_fullStr The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons
title_full_unstemmed The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons
title_sort ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/c19edda13452426aba259acb5f3878f4
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