Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer

Budzinski et al use bivalent ligands, BRET assays and radioligand competition to demonstrate a specific interaction between two receptors associated with neuropsychiatric diseases and addiction, dopamine D3 (D3R) and neurotensin receptor 1. They show that the bivalent ligands promote endosomal traff...

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Autores principales:	Julian Budzinski, Simone Maschauer, Hiroyuki Kobayashi, Pierre Couvineau, Hannah Vogt, Peter Gmeiner, Anna Roggenhofer, Olaf Prante, Michel Bouvier, Dorothee Weikert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c19eeb6e87c441afa774ebbb7ead711b
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spelling	oai:doaj.org-article:c19eeb6e87c441afa774ebbb7ead711b2021-12-02T17:19:12ZBivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer10.1038/s42003-021-02574-42399-3642https://doaj.org/article/c19eeb6e87c441afa774ebbb7ead711b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02574-4https://doaj.org/toc/2399-3642Budzinski et al use bivalent ligands, BRET assays and radioligand competition to demonstrate a specific interaction between two receptors associated with neuropsychiatric diseases and addiction, dopamine D3 (D3R) and neurotensin receptor 1. They show that the bivalent ligands promote endosomal trafficking of D3R, suggesting a potential role for dimerization in vivo.Julian BudzinskiSimone MaschauerHiroyuki KobayashiPierre CouvineauHannah VogtPeter GmeinerAnna RoggenhoferOlaf PranteMichel BouvierDorothee WeikertNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Julian Budzinski Simone Maschauer Hiroyuki Kobayashi Pierre Couvineau Hannah Vogt Peter Gmeiner Anna Roggenhofer Olaf Prante Michel Bouvier Dorothee Weikert Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer
description	Budzinski et al use bivalent ligands, BRET assays and radioligand competition to demonstrate a specific interaction between two receptors associated with neuropsychiatric diseases and addiction, dopamine D3 (D3R) and neurotensin receptor 1. They show that the bivalent ligands promote endosomal trafficking of D3R, suggesting a potential role for dimerization in vivo.
format	article
author	Julian Budzinski Simone Maschauer Hiroyuki Kobayashi Pierre Couvineau Hannah Vogt Peter Gmeiner Anna Roggenhofer Olaf Prante Michel Bouvier Dorothee Weikert
author_facet	Julian Budzinski Simone Maschauer Hiroyuki Kobayashi Pierre Couvineau Hannah Vogt Peter Gmeiner Anna Roggenhofer Olaf Prante Michel Bouvier Dorothee Weikert
author_sort	Julian Budzinski
title	Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer
title_short	Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer
title_full	Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer
title_fullStr	Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer
title_full_unstemmed	Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer
title_sort	bivalent ligands promote endosomal trafficking of the dopamine d3 receptor-neurotensin receptor 1 heterodimer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c19eeb6e87c441afa774ebbb7ead711b
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Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer

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