Differences in the Binding Affinity of an HIV-1 V2 Apex-Specific Antibody for the SIV<sub>smm/mac</sub> Envelope Glycoprotein Uncouple Antibody-Dependent Cellular Cytotoxicity from Neutralization

ABSTRACT As a consequence of their independent evolutionary origins in apes and Old World monkeys, human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency viruses of the SIVsmm/mac lineage express phylogenetically and antigenically distinct envelope glycoproteins. Thus, HIV-1 Env-spe...

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Auteurs principaux: Benjamin von Bredow, Raiees Andrabi, Michael Grunst, Andres G. Grandea, Khoa Le, Ge Song, Zachary T. Berndsen, Katelyn Porter, Jesper Pallesen, Andrew B. Ward, Dennis R. Burton, David T. Evans
Format: article
Langue:EN
Publié: American Society for Microbiology 2019
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Accès en ligne:https://doaj.org/article/c1a57cf58e484610983b2c42b864ce7c
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