Organocatalytic Asymmetric [2 + 4] Cycloadditions of 3-Vinylindoles with <i>ortho</i>-Quinone Methides
Catalytic asymmetric [2 + 4] cycloadditions of 3-vinylindoles with <i>ortho</i>-quinone methides and their precursors were carried out in the presence of chiral phosphoric acid to afford a series of indole-containing chroman derivatives with structural diversity in overall high yields (u...
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/c1a76d72e781497ebb33bd808c65632d |
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| Sumario: | Catalytic asymmetric [2 + 4] cycloadditions of 3-vinylindoles with <i>ortho</i>-quinone methides and their precursors were carried out in the presence of chiral phosphoric acid to afford a series of indole-containing chroman derivatives with structural diversity in overall high yields (up to 98%), good diastereoselectivities (up to 93:7 dr) and moderate to excellent enantioselectivities (up to 98% ee). This approach not only enriches the chemistry of catalytic asymmetric cycloadditions involving 3-vinylindoles but is also useful for synthesizing chiral chroman derivatives. |
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