Alterations in the histological features of the intestinal mucosa in malnourished adults of Bangladesh

Abstract There is paucity of knowledge on the histological features of the intestinal mucosa in malnourished adults of Bangladesh. The purpose of the study was to explore the histological features of the intestinal mucosa in malnourished adults of Bangladesh and to compare the findings with their we...

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Autores principales:	Md. Shabab Hossain, S. M. Khodeza Nahar Begum, M. Masudur Rahman, Ramendra Nath Mazumder, Mashud Parvez, Md. Amran Gazi, Md. Mehedi Hasan, Shah Mohammad Fahim, Subhasish Das, Mustafa Mahfuz, Shafiqul Alam Sarker, Tahmeed Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c1b497d3a0464c2a90381db13d363988
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spelling	oai:doaj.org-article:c1b497d3a0464c2a90381db13d3639882021-12-02T13:23:50ZAlterations in the histological features of the intestinal mucosa in malnourished adults of Bangladesh10.1038/s41598-021-82079-62045-2322https://doaj.org/article/c1b497d3a0464c2a90381db13d3639882021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82079-6https://doaj.org/toc/2045-2322Abstract There is paucity of knowledge on the histological features of the intestinal mucosa in malnourished adults of Bangladesh. The purpose of the study was to explore the histological features of the intestinal mucosa in malnourished adults of Bangladesh and to compare the findings with their well-nourished counterparts. 64 adults (37 malnourished with body mass index, BMI < 18.5 kg/m2 and 27 controls with BMI > 18.5 kg/m2) from the Bangladesh Environmental Enteric Dysfunction (BEED) study, who underwent upper-gastrointestinal endoscopy, were selected for this study. With a view to address the association of environmental enteric dysfunction (EED) with malnutrition, upper-gastrointestinal endoscopy was performed and mucosal biopsies from the distal duodenum were studied for histopathology. Villous height, crypt depth, and presence of inflammatory infiltrates in lamina propria were investigated. Bivariate analysis was performed to quantify the relation between malnutrition and the histological features. About 95% adults, irrespective of nutritional status, were diagnosed to have chronic non-specific duodenitis on histopathology. Malnourished adults suffered significantly more from chronic active duodenitis compared to their well-nourished counterparts (p = 0.003). Malnourished adults also had significantly higher frequency of subtotal villous atrophy, crypt hyperplasia and marked cellular infiltration in the lamina propria than the healthy controls (p < 0.05).Md. Shabab HossainS. M. Khodeza Nahar BegumM. Masudur RahmanRamendra Nath MazumderMashud ParvezMd. Amran GaziMd. Mehedi HasanShah Mohammad FahimSubhasish DasMustafa MahfuzShafiqul Alam SarkerTahmeed AhmedNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Md. Shabab Hossain S. M. Khodeza Nahar Begum M. Masudur Rahman Ramendra Nath Mazumder Mashud Parvez Md. Amran Gazi Md. Mehedi Hasan Shah Mohammad Fahim Subhasish Das Mustafa Mahfuz Shafiqul Alam Sarker Tahmeed Ahmed Alterations in the histological features of the intestinal mucosa in malnourished adults of Bangladesh
description	Abstract There is paucity of knowledge on the histological features of the intestinal mucosa in malnourished adults of Bangladesh. The purpose of the study was to explore the histological features of the intestinal mucosa in malnourished adults of Bangladesh and to compare the findings with their well-nourished counterparts. 64 adults (37 malnourished with body mass index, BMI < 18.5 kg/m2 and 27 controls with BMI > 18.5 kg/m2) from the Bangladesh Environmental Enteric Dysfunction (BEED) study, who underwent upper-gastrointestinal endoscopy, were selected for this study. With a view to address the association of environmental enteric dysfunction (EED) with malnutrition, upper-gastrointestinal endoscopy was performed and mucosal biopsies from the distal duodenum were studied for histopathology. Villous height, crypt depth, and presence of inflammatory infiltrates in lamina propria were investigated. Bivariate analysis was performed to quantify the relation between malnutrition and the histological features. About 95% adults, irrespective of nutritional status, were diagnosed to have chronic non-specific duodenitis on histopathology. Malnourished adults suffered significantly more from chronic active duodenitis compared to their well-nourished counterparts (p = 0.003). Malnourished adults also had significantly higher frequency of subtotal villous atrophy, crypt hyperplasia and marked cellular infiltration in the lamina propria than the healthy controls (p < 0.05).
format	article
author	Md. Shabab Hossain S. M. Khodeza Nahar Begum M. Masudur Rahman Ramendra Nath Mazumder Mashud Parvez Md. Amran Gazi Md. Mehedi Hasan Shah Mohammad Fahim Subhasish Das Mustafa Mahfuz Shafiqul Alam Sarker Tahmeed Ahmed
author_facet	Md. Shabab Hossain S. M. Khodeza Nahar Begum M. Masudur Rahman Ramendra Nath Mazumder Mashud Parvez Md. Amran Gazi Md. Mehedi Hasan Shah Mohammad Fahim Subhasish Das Mustafa Mahfuz Shafiqul Alam Sarker Tahmeed Ahmed
author_sort	Md. Shabab Hossain
title	Alterations in the histological features of the intestinal mucosa in malnourished adults of Bangladesh
title_short	Alterations in the histological features of the intestinal mucosa in malnourished adults of Bangladesh
title_full	Alterations in the histological features of the intestinal mucosa in malnourished adults of Bangladesh
title_fullStr	Alterations in the histological features of the intestinal mucosa in malnourished adults of Bangladesh
title_full_unstemmed	Alterations in the histological features of the intestinal mucosa in malnourished adults of Bangladesh
title_sort	alterations in the histological features of the intestinal mucosa in malnourished adults of bangladesh
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c1b497d3a0464c2a90381db13d363988
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Alterations in the histological features of the intestinal mucosa in malnourished adults of Bangladesh

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