Evaluation of Potential Pain Biomarkers in Saliva and Pain Perception After Corneal Advanced Surface Ablation Surgery

Eva M Sobas,1,2 Amanda Vázquez,1,2 Sebastián Videla,3 Roberto Reinoso,1,4,5 Itziar Fernández,1,5 Carmen Garcia-Vazquez,1 Miguel J Maldonado,1,6 J Carlos Pastor1,6,7 1IOBA Eye Institute, University of Valladolid, Valladolid, Spain; 2Nursery Faculty, University of Vall...

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Autores principales:	Sobas EM, Vázquez A, Videla S, Reinoso R, Fernández I, Garcia-Vazquez C, Maldonado MJ, Pastor JC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	biomarkers ocular pain advanced surface ablation Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c1b5cfb0bfaa4358bdf9f6676ddde56f
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spelling	oai:doaj.org-article:c1b5cfb0bfaa4358bdf9f6676ddde56f2021-12-02T11:34:48ZEvaluation of Potential Pain Biomarkers in Saliva and Pain Perception After Corneal Advanced Surface Ablation Surgery1177-5483https://doaj.org/article/c1b5cfb0bfaa4358bdf9f6676ddde56f2020-03-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-potential-pain-biomarkers-in-saliva-and-pain-perception--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Eva M Sobas,1,2 Amanda Vázquez,1,2 Sebastián Videla,3 Roberto Reinoso,1,4,5 Itziar Fernández,1,5 Carmen Garcia-Vazquez,1 Miguel J Maldonado,1,6 J Carlos Pastor1,6,7 1IOBA Eye Institute, University of Valladolid, Valladolid, Spain; 2Nursery Faculty, University of Valladolid, Valladolid, Spain; 3Clinical Research Support Unit, Clinical Pharmacology Department, Bellvitge University Hospital/Bellvitge Biomedical Research Institute (IDIBELL)/University of Barcelona, L’Hospitalet de Llobregat, Barcelona; 4Visión I+D, University of Valladolid, Valladolid, Spain; 5Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valladolid, Spain; 6Department of Surgery, Ophthalmology, Otorhinolaryngology and Physiotherapy, Faculty of Medicine, University of Valladolid, Valladolid, Spain; 7Department of Ophthalmology, Hospital Clínico Universitario, Valladolid, SpainCorrespondence: Eva M Sobas Email eva@ioba.med.uva.esPurpose: To evaluate the evolution of a set of proposed pain biomarkers in the saliva of subjects following Advanced Surface Ablation (ASA), in order to determine their validity as objective pain measures.Methods: A multicenter, prospective, and descriptive study was carried out to assess the variations between biomarkers and perceived pain. The Inclusion criteria were healthy subjects who underwent a bilateral, alcohol-assisted surface ablation with epithelial removal (ASA). Pain intensity before and after surgery was assessed by Visual Analog Scale (VAS) and the Numeric Pain Rating Scale (NPRS). Cortisol, sAA, sIgA, testosterone, and sTNFαRII were assayed at four-time points (V0, baseline; V1, pre-surgery; V2, 1 hr post-surgery, and V3, 72 hrs post-surgery). Comorbidities and Hospital Anxiety and Depression (HADS) questionnaires were administrated before and at 6 hrs after the surgery. All patients were treated with cold patches, topical steroids, topical cold antibiotics, and benzodiazepines after ASA surgery. A descriptive analysis of biomarkers and pain intensity evolution and the agreement between biomarkers and pain was performed.Results: Concentration of sIgA and sTNFαRII post-surgery was significantly higher at each visit compared to baseline (p-value:  0.053, p-value: < 0.001, respectively). Relations between VAS scale score and putative biomarker variations were not statistically significant except for the sIgA but only at visit 0 (p-value:  0.024). The HADS questionnaire showed anxiety scores between 0 and 7 in all patients before and at 6 hrs after surgery.Conclusion: In this study, sIgA and sTNFαRII are the two potential biomarkers that present correlation with the VAS and these salivary substances showed acceptable levels of reproducibility in healthy subjects.Keywords: biomarkers, ocular pain, advanced surface ablationSobas EMVázquez AVidela SReinoso RFernández IGarcia-Vazquez CMaldonado MJPastor JCDove Medical Pressarticlebiomarkersocular painadvanced surface ablationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 613-623 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomarkers ocular pain advanced surface ablation Ophthalmology RE1-994
spellingShingle	biomarkers ocular pain advanced surface ablation Ophthalmology RE1-994 Sobas EM Vázquez A Videla S Reinoso R Fernández I Garcia-Vazquez C Maldonado MJ Pastor JC Evaluation of Potential Pain Biomarkers in Saliva and Pain Perception After Corneal Advanced Surface Ablation Surgery
description	Eva M Sobas,1,2 Amanda Vázquez,1,2 Sebastián Videla,3 Roberto Reinoso,1,4,5 Itziar Fernández,1,5 Carmen Garcia-Vazquez,1 Miguel J Maldonado,1,6 J Carlos Pastor1,6,7 1IOBA Eye Institute, University of Valladolid, Valladolid, Spain; 2Nursery Faculty, University of Valladolid, Valladolid, Spain; 3Clinical Research Support Unit, Clinical Pharmacology Department, Bellvitge University Hospital/Bellvitge Biomedical Research Institute (IDIBELL)/University of Barcelona, L’Hospitalet de Llobregat, Barcelona; 4Visión I+D, University of Valladolid, Valladolid, Spain; 5Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valladolid, Spain; 6Department of Surgery, Ophthalmology, Otorhinolaryngology and Physiotherapy, Faculty of Medicine, University of Valladolid, Valladolid, Spain; 7Department of Ophthalmology, Hospital Clínico Universitario, Valladolid, SpainCorrespondence: Eva M Sobas Email eva@ioba.med.uva.esPurpose: To evaluate the evolution of a set of proposed pain biomarkers in the saliva of subjects following Advanced Surface Ablation (ASA), in order to determine their validity as objective pain measures.Methods: A multicenter, prospective, and descriptive study was carried out to assess the variations between biomarkers and perceived pain. The Inclusion criteria were healthy subjects who underwent a bilateral, alcohol-assisted surface ablation with epithelial removal (ASA). Pain intensity before and after surgery was assessed by Visual Analog Scale (VAS) and the Numeric Pain Rating Scale (NPRS). Cortisol, sAA, sIgA, testosterone, and sTNFαRII were assayed at four-time points (V0, baseline; V1, pre-surgery; V2, 1 hr post-surgery, and V3, 72 hrs post-surgery). Comorbidities and Hospital Anxiety and Depression (HADS) questionnaires were administrated before and at 6 hrs after the surgery. All patients were treated with cold patches, topical steroids, topical cold antibiotics, and benzodiazepines after ASA surgery. A descriptive analysis of biomarkers and pain intensity evolution and the agreement between biomarkers and pain was performed.Results: Concentration of sIgA and sTNFαRII post-surgery was significantly higher at each visit compared to baseline (p-value:  0.053, p-value: < 0.001, respectively). Relations between VAS scale score and putative biomarker variations were not statistically significant except for the sIgA but only at visit 0 (p-value:  0.024). The HADS questionnaire showed anxiety scores between 0 and 7 in all patients before and at 6 hrs after surgery.Conclusion: In this study, sIgA and sTNFαRII are the two potential biomarkers that present correlation with the VAS and these salivary substances showed acceptable levels of reproducibility in healthy subjects.Keywords: biomarkers, ocular pain, advanced surface ablation
format	article
author	Sobas EM Vázquez A Videla S Reinoso R Fernández I Garcia-Vazquez C Maldonado MJ Pastor JC
author_facet	Sobas EM Vázquez A Videla S Reinoso R Fernández I Garcia-Vazquez C Maldonado MJ Pastor JC
author_sort	Sobas EM
title	Evaluation of Potential Pain Biomarkers in Saliva and Pain Perception After Corneal Advanced Surface Ablation Surgery
title_short	Evaluation of Potential Pain Biomarkers in Saliva and Pain Perception After Corneal Advanced Surface Ablation Surgery
title_full	Evaluation of Potential Pain Biomarkers in Saliva and Pain Perception After Corneal Advanced Surface Ablation Surgery
title_fullStr	Evaluation of Potential Pain Biomarkers in Saliva and Pain Perception After Corneal Advanced Surface Ablation Surgery
title_full_unstemmed	Evaluation of Potential Pain Biomarkers in Saliva and Pain Perception After Corneal Advanced Surface Ablation Surgery
title_sort	evaluation of potential pain biomarkers in saliva and pain perception after corneal advanced surface ablation surgery
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/c1b5cfb0bfaa4358bdf9f6676ddde56f
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Evaluation of Potential Pain Biomarkers in Saliva and Pain Perception After Corneal Advanced Surface Ablation Surgery

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