An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal

The pre-mRNA splicing factor U2AF65 recognizes 3′ splice sites in human gene transcripts, but the details are not fully understood. Here, the authors report U2AF65 structures and single molecule FRET that reveal mechanistic insights into splice site recognition.

Guardado en:

Detalles Bibliográficos
Autores principales:	Anant A. Agrawal, Enea Salsi, Rakesh Chatrikhi, Steven Henderson, Jermaine L. Jenkins, Michael R. Green, Dmitri N. Ermolenko, Clara L. Kielkopf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1b792d28aba471e81c175eb71e73c9e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c1b792d28aba471e81c175eb71e73c9e
record_format	dspace
spelling	oai:doaj.org-article:c1b792d28aba471e81c175eb71e73c9e2021-12-02T16:57:29ZAn extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal10.1038/ncomms109502041-1723https://doaj.org/article/c1b792d28aba471e81c175eb71e73c9e2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10950https://doaj.org/toc/2041-1723The pre-mRNA splicing factor U2AF65 recognizes 3′ splice sites in human gene transcripts, but the details are not fully understood. Here, the authors report U2AF65 structures and single molecule FRET that reveal mechanistic insights into splice site recognition.Anant A. AgrawalEnea SalsiRakesh ChatrikhiSteven HendersonJermaine L. JenkinsMichael R. GreenDmitri N. ErmolenkoClara L. KielkopfNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anant A. Agrawal Enea Salsi Rakesh Chatrikhi Steven Henderson Jermaine L. Jenkins Michael R. Green Dmitri N. Ermolenko Clara L. Kielkopf An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal
description	The pre-mRNA splicing factor U2AF65 recognizes 3′ splice sites in human gene transcripts, but the details are not fully understood. Here, the authors report U2AF65 structures and single molecule FRET that reveal mechanistic insights into splice site recognition.
format	article
author	Anant A. Agrawal Enea Salsi Rakesh Chatrikhi Steven Henderson Jermaine L. Jenkins Michael R. Green Dmitri N. Ermolenko Clara L. Kielkopf
author_facet	Anant A. Agrawal Enea Salsi Rakesh Chatrikhi Steven Henderson Jermaine L. Jenkins Michael R. Green Dmitri N. Ermolenko Clara L. Kielkopf
author_sort	Anant A. Agrawal
title	An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal
title_short	An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal
title_full	An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal
title_fullStr	An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal
title_full_unstemmed	An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal
title_sort	extended u2af65–rna-binding domain recognizes the 3′ splice site signal
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c1b792d28aba471e81c175eb71e73c9e
work_keys_str_mv	AT anantaagrawal anextendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT eneasalsi anextendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT rakeshchatrikhi anextendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT stevenhenderson anextendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT jermaineljenkins anextendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT michaelrgreen anextendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT dmitrinermolenko anextendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT claralkielkopf anextendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT anantaagrawal extendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT eneasalsi extendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT rakeshchatrikhi extendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT stevenhenderson extendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT jermaineljenkins extendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT michaelrgreen extendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT dmitrinermolenko extendedu2af65rnabindingdomainrecognizesthe3splicesitesignal AT claralkielkopf extendedu2af65rnabindingdomainrecognizesthe3splicesitesignal
_version_	1718382589033578496

An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal

Ejemplares similares