Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy

Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here, the authors generate single-drug nanoparticles by hybridising lysomotropic detergents and the bisaminoquinoline-based autophagy inhibitor, and show thei...

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Autores principales:	Zhao Ma, Jin Li, Kai Lin, Mythili Ramachandran, Dalin Zhang, Megan Showalter, Cristabelle De Souza, Aaron Lindstrom, Lucas N. Solano, Bei Jia, Shiro Urayama, Yuyou Duan, Oliver Fiehn, Tzu-yin Lin, Minyong Li, Yuanpei Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1bb3fa64a58463a9a7b7509b2e89b61
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spelling	oai:doaj.org-article:c1bb3fa64a58463a9a7b7509b2e89b612021-12-02T18:50:53ZPharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy10.1038/s41467-020-18399-42041-1723https://doaj.org/article/c1bb3fa64a58463a9a7b7509b2e89b612020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18399-4https://doaj.org/toc/2041-1723Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here, the authors generate single-drug nanoparticles by hybridising lysomotropic detergents and the bisaminoquinoline-based autophagy inhibitor, and show their therapeutic potential as autophagy-inhibition based combination therapy.Zhao MaJin LiKai LinMythili RamachandranDalin ZhangMegan ShowalterCristabelle De SouzaAaron LindstromLucas N. SolanoBei JiaShiro UrayamaYuyou DuanOliver FiehnTzu-yin LinMinyong LiYuanpei LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhao Ma Jin Li Kai Lin Mythili Ramachandran Dalin Zhang Megan Showalter Cristabelle De Souza Aaron Lindstrom Lucas N. Solano Bei Jia Shiro Urayama Yuyou Duan Oliver Fiehn Tzu-yin Lin Minyong Li Yuanpei Li Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy
description	Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here, the authors generate single-drug nanoparticles by hybridising lysomotropic detergents and the bisaminoquinoline-based autophagy inhibitor, and show their therapeutic potential as autophagy-inhibition based combination therapy.
format	article
author	Zhao Ma Jin Li Kai Lin Mythili Ramachandran Dalin Zhang Megan Showalter Cristabelle De Souza Aaron Lindstrom Lucas N. Solano Bei Jia Shiro Urayama Yuyou Duan Oliver Fiehn Tzu-yin Lin Minyong Li Yuanpei Li
author_facet	Zhao Ma Jin Li Kai Lin Mythili Ramachandran Dalin Zhang Megan Showalter Cristabelle De Souza Aaron Lindstrom Lucas N. Solano Bei Jia Shiro Urayama Yuyou Duan Oliver Fiehn Tzu-yin Lin Minyong Li Yuanpei Li
author_sort	Zhao Ma
title	Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy
title_short	Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy
title_full	Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy
title_fullStr	Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy
title_full_unstemmed	Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy
title_sort	pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c1bb3fa64a58463a9a7b7509b2e89b61
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Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy

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